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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Accelerated gastric ulcer healing in thyroxine-treated rats: roles of gastric acid, mucus, and inflammatory response
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Accelerated gastric ulcer healing in thyroxine-treated rats: roles of gastric acid, mucus, and inflammatory response

机译：甲状腺素处理大鼠加速胃溃疡愈合：胃酸，粘液和炎症反应的作用

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摘要

The roles of gastric acid, mucus, and inflammation on the pro-ulcer-healing effect of thyroid hormone were investigated. Male Wistar rats were randomly divided into four groups: control, thyroidectomised, thyroidectomised with thyroxine treatment (100 mu g.kg(-1).day(-1)), and sham-operated animals treated with thyroxine. Thirty-five days after thyroidectomy, sham surgery, or thyroxine treatment, an ulcer was experimentally induced. Healing was assessed 3, 7, and 10 days post-ulceration by measurement of the ulcer area, gastric mucus and acid secretion, and neutrophil lymphocyte ratio (NLR) as an index of inflammation. By day 10, the ulcer area had decreased in all groups. Recovery was significantly greater (P 0.05) in thyroxine-treated rats (78.5% +/- 1.6% reduction in ulcer area) than in controls (72.3% +/- 1.2% reduction) or thyroidectomised rats (63.3% +/- 1.9% reduction). Thyroxine-treated animals also had the highest reduction in NLR (65.0% +/- 2.5%). Mucus secretion was significantly lower (P 0.05) in thyroidectomised rats by days 3 and 7. Furthermore, by day 10, the concentration of basal acid decreased by 77.4% +/- 2.6% in thyroxine-treated, 65.0% +/- 0.0% in control, and 51.5% +/- 3.3% in thyroidectomised rats. We conclude that thyroxine accelerates gastric ulcer healing by altering mucus and acid secretion and reducing NLR.
机译：研究了胃酸，粘液和炎症对甲状腺激素的促溃疡愈合作用的作用。将雄性Wistar大鼠随机分为四组：对照，甲状腺切除术，甲状腺素治疗（100 mu G.kg（-1）.nde（-1））和用甲状腺素处理的假手术动物。甲状腺切除术，假手术或甲状腺素处理后三十五天，进行了实验诱导的溃疡。通过测量溃疡面积，胃粘液和酸分泌物和中性粒细胞淋巴细胞比（NLR）作为炎症指标，评估愈合3,7和10天。在第10天，溃疡面积在所有群体中减少。在甲状腺素处理的大鼠中恢复明显较大（P <0.05）（降低溃疡面积减少78.5％+/- 1.6％）（减少72.3％+/- 1.2％）或甲状腺切除大鼠（63.3％+/-减少1.9％）。甲状腺素处理的动物还具有最高的NLR（65.0％+/- 2.5％）。在第3天和第7天，粘液分泌在甲状腺切除术大鼠中显着降低（P <0.05）。此外，在第10天，基础酸的浓度降低77.4％+/- 2.6％在甲状腺处理中，65.0％+/- 0.0％的对照，甲状腺切除术大鼠中的51.5％+/- 3.3％。我们得出结论，甲状腺素通过改变粘液和酸分泌并减少NLR来加速胃溃疡愈合。

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