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首页> 外文期刊>Balkan journal of medical genetics: BJMG >MOLECULAR AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF COMPLETE HYDATIDIFORM MOLES
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MOLECULAR AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF COMPLETE HYDATIDIFORM MOLES

机译：完全瓦湿钼的分子和免疫组织化学特性

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摘要

Molar pregnancy is a gestational trophoblastic disease that belongs to the category of precancerous lesions. On the other end of the spectrum are gestational trophoblastic neoplasms such as invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor, which are considered malignant tumors. Based on defined histopathological criteria, molar pregnancy is divided into partial and complete hydatidiform mole. Especially in the case of early complete mole, the diagnosis can be quite challenging and often necessitates additional molecular or immunohistochemical methods. The aim of this study was to assess the importance of additional molecular and immunohistochemical methods to accurately diagnose complete hydatidiform mole and to stress the importance of correct diagnosis and close followup of these patients. A total of 367 consecutive cases of spontaneous abortion were analyzed in a 3-year period. Eight cases with histopathological diagnosis of complete molar pregnancy were selected for further analysis. Apart from standard microscopic analysis, additional molecular and immunohistochemical analyses were performed in all eight cases. Most of the histopathological characteristics of complete molar pregnancy were present in all cases, together with complete absence of positivity for the p57 immunohistochemical marker in the cytotrophoblasts and villous stromal cells. The molecular analysis revealed androgenetic diploidy in seven cases and biparental diploidy in one case with more than three consecutive complete molar pregnancies. Additional immunohistochemical and molecular methods can considerably aid in the correct diagnosis of molar pregnancy.
机译：摩尔妊娠是一种妊娠期滋养细胞疾病，属于癌前病变的类别。在频谱的另一端是妊娠期滋养细胞肿瘤，如侵入性摩尔，甘露曲序列，胎盘位点滋养肿瘤和上皮滋养细胞肿瘤，被认为是恶性肿瘤。基于定义的组织病理学标准，摩尔妊娠分为局部和完全的瓦尔膜。特别是在早期完全摩尔的情况下，诊断可能是非常具有挑战性的，并且通常需要额外的分子或免疫组化方法。本研究的目的是评估额外的分子和免疫组织化学方法的重要性，以准确诊断完整的瓦尔膜，并强调正确诊断和密切关注这些患者的重要性。在3年期间，共分析了367例自发流产。选择八例具有完全摩尔妊娠的组织病理学诊断以进一步分析。除标准显微镜分析外，在所有8个案例中进行了额外的分子和免疫组化分析。在所有情况下，全部存在完全摩尔妊娠的大多数组织病理学特征，在细胞脱发和绒毛间质量细胞中完全没有阳性的P57免疫组织化学标记。分子分析在一个连续三种完全磨牙妊娠的一个案例中显示出七种病例和母增剂的肥胖子系统。额外的免疫组织化学和分子方法可以显着帮助正确诊断摩尔妊娠。

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