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首页> 外文期刊>Balkan journal of medical genetics: BJMG >`FAMILY HISTORY AS AN IMPORTANT FACTOR FOR STRATIFYING PARTICIPANTS IN GENETIC STUDIES OF MAJOR DEPRESSION
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`FAMILY HISTORY AS AN IMPORTANT FACTOR FOR STRATIFYING PARTICIPANTS IN GENETIC STUDIES OF MAJOR DEPRESSION

机译：“家族史作为分层参与者在重大抑郁症遗传学研究中的重要因素

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摘要

Depression is estimated to affect 350 million people worldwide. The World Mental Health Survey conducted in 17 countries found that, on average, about one in 20 people reported having an episode of depression in the previous year. Although depression has been shown to be moderately heritable by studies conducted in the past, the search for its so-called missing heritability has so far been unsuccessful. The difficulty in identifying common genetic variants predisposing to depression could be due to large sample sizes needed to detect small effects on genetic risk and the heterogeneous nature of major depressive disorder (MDD). The aim of our study was to determine whether there was a connection between a family history of depression in MDD patients and the presence of putative risk variants in the well-studied SLC6A4, COMT and PCLO genes. We analyzed 133 patients with MDD (30.0% with a positive family history for MDD and 70.0% sporadic cases) and compared them to 279 healthy controls. When comparing all the depressed patients to controls, no significant differences in genotype and allele distributions were detected. After stratifying patients according to their family history, the PCLO rs2522833 C allele was shown to be significantly less common in patients with a positive family history (p = 0.001), indicating a possible difference in the genetic structure of MDD between familial and sporadic cases and a less important role of the common genetic risk variants for the development of MDD in familial cases.
机译：估计抑郁症估计为全世界3.5亿人。在17个国家进行的世界精神卫生调查发现，平均而言，据报道，据报道，据报道，前一年的一集。虽然过去的研究表明抑郁症是适度的遗传遗传，但到目前为止，对所谓的遗传性的搜索是不成功的。识别易受抑郁症的常见遗传变异的难度可能是由于检测对遗传风险的小效果和主要抑郁症（MDD）的异质性质所需的大量样本尺寸。我们的研究目的是确定MDD患者抑郁症家族史是否存在联系，以及在研究良好的SLC6A4，COMT和PCLO基因中存在推定风险变体。我们分析了133例MDD患者（30.0％，占MDD的阳性家庭历史，70.0％散发病例），并将其与279例健康对照进行比较。当比较所有抑郁的患者对控制患者进行比较时，检测到基因型和等位基因分布没有显着差异。在分层患者根据他们的家族史，PCLO RS2522833 C等位基因显示在阳性家庭历史（P = 0.001）的患者中显着不那么常见，表明家族和散发病例之间MDD遗传结构的可能差异常见的遗传风险变异在家庭病例中MDD开发的常见遗传风险变异不太重要的作用。

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