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首页> 外文期刊>Balkan journal of medical genetics: BJMG >POLYMORPHISM OF THE ADRB2 rs1042713 GENE IS NOT ASSOCIATED WITH SPONTANEOUS PRETERM BIRTH: ANALYSES IN A SLOVENIAN SAMPLE AND META ANALYSIS
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POLYMORPHISM OF THE ADRB2 rs1042713 GENE IS NOT ASSOCIATED WITH SPONTANEOUS PRETERM BIRTH: ANALYSES IN A SLOVENIAN SAMPLE AND META ANALYSIS

机译：ADRB2 RS1042713基因的多态性与自发早产无关：在斯洛文尼亚样本和Meta分析中分析

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摘要

The beta-2-adrenergic receptor (ADRB2) gene has an important impact on smooth muscle relaxation, including the smooth muscles of the uterus. The results of previously published studies of the association between the ADRB2 rs1042713 polymorphism and spontaneous preterm birth (SPTB) were inconsistent. We evaluated the association between ADRB2 and SPTB in a case-control association study in a Slovenian sample population and performed a meta analysis of previously published studies. No association was found between the polymorphism in the ADRB2 gene and SPTB in the Slovenian sample of 98 SPTB patients and 135 controls under dominant [chi(2) = 0.01, p = 0.92, odds ratio (OR) = 1.03, 95% confidence interval (95% CI) = 0.52-2.04), recessive (chi(2) = 0.01, p = 0.92, OR = 0.98, 95% CI = 0.57-1.70) and codominant genetic models (chi(2) = 0.01, p = 0.92, OR = 0.99, 95% CI = 0.59-1.68). The meta analysis of a pooled sample of 404 SPTB patients and 878 controls suggested no association of ADRB2 polymorphism and SPTB under dominant (OR = 1.12, 95% CI = 0.81-1.54) and recessive genetic models (OR = 0.84, 95% CI = 0.64-1.12). These findings suggest no association between the ADRB2 rs1042713 gene polymorphism and SPTB. Further association studies with larger sample sizes are needed.
机译：β-2-肾上腺素能受体（ADRB2）基因对平滑肌松弛具有重要影响，包括子宫的平滑肌。先前公布的ADRB2 rs1042713多态性和自发早产（SPTB）之间的关联研究的结果不一致。我们在斯洛文尼亚样品群体中的病例控制协会研究中评估了ADRB2和SPTB之间的关联，并对先前公布的研究进行了META分析。在ADRB2基因和SPTB的多态性中没有发现在98例SPTB患者的斯洛文尼亚患者和135名对照下的占主导地位[CHI（2）= 0.01，P = 0.92，差距（或）= 1.03，95％置信区间之间（95％CI）= 0.52-2.04），隐性（CHI（2）= 0.01，p = 0.92，或= 0.98,95％CI = 0.57-1.70）和CODOMINANT遗传模型（CHI（2）= 0.01，P = 0.92，或= 0.99,95％CI = 0.59-1.68））。 404个SPTB患者和878例对照的汇总样品的META分析表明，非ADRB2多态性和SPTB在占优势（或= 1.12,95％CI = 0.81-1.54）和隐性遗传模型（或= 0.84,95％CI = 0.64-1.12）。这些发现表明ADRB2 RS1042713基因多态性和SPTB之间没有关联。需要进一步的具有较大样本尺寸的关联研究。

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