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首页> 外文期刊>Cancer prevention research. >A Distinct Epidemiologic Pattern of Precancerous Lesions of Esophageal Squamous Cell Carcinoma in a High-risk Area of Huai'an, Jiangsu Province, China
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A Distinct Epidemiologic Pattern of Precancerous Lesions of Esophageal Squamous Cell Carcinoma in a High-risk Area of Huai'an, Jiangsu Province, China

机译：中国江苏省淮安高风险地区食管鳞状细胞癌的一种独特的流行病学模式

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摘要

Better understanding of esophageal precancerous lesions (EPL) can inform prevention strategies for esophageal squamous cell carcinoma (ESCC). Here, a cross-sectional epidemiologic study based on the Early Diagnosis and Early Treatment Project of Esophageal Cancer database from 2011 to 2017 was performed to fully investigate and characterize the epidemiology of EPL in rural Huai'an District. Data of 11,518 participants ages 35-75 years were collected through face-to-face interviews by questionnaire. Participants underwent a routine endoscopy examination, tissues were biopsied, and diagnosed according to the histologic criteria of dysplasia. Unconditional univariate and multivariate logistic regression analyses were performed to obtain crude and adjusted odds ratios and corresponding 95% confidence intervals, respectively. A total of 667 subjects were diagnosed with EPL. Factors associated with an increased risk of EPL included: drinking shallow well water and surface water, irregular diet, excessive smoking, exposure to secondhand smoke, consumption of corn, corn flour, pickled food, fried food, and hot food, and having a history of digestive system diseases. In addition, liquor use, but not other alcohol types, contributed to risk of EPL. Consumption of deep well water and vegetables, fruits, and animal livers were associated with lower EPL risk. This study suggested a completely distinct pattern that alcohol use plays only a minor role in EPL and excessive tobacco use shows a significant association in rural Huai'an District, while eating habits and environmental exposure may be the dominant factors. This work may be promising to provide scientific evidence to support primary prevention of ESCC in this region.
机译：更好地了解食管癌癌前病变（EPL）可以告知食管鳞状细胞癌（ESCC）的预防策略。在此，根据2011年至2017年从早期诊断和早期治疗项目的横截面流行病学研究进行了2011年至2017年，以全面调查和表征淮安区农村EPL流行病学。通过问卷面对面对面的面试，收集了11,518岁的参与者的数据。参与者经历了常规内窥镜检查检查，组织是活组织检查，并根据发育不良的组织学标准进行诊断。进行无条件的单变量和多变量逻辑回归分析，以获得粗糙和调整后的大量比例，并分别进行95％的置信区间。共有667名受试者被诊断为EPL。随着EPL风险增加的因素包括：饮用浅水水和地表水，不规则的饮食，过度吸烟，暴露于二手烟雾，消费玉米，玉米粉，腌制食品，油炸食品和热食，并有历史消化系统疾病。此外，白酒使用，但不是其他酒精类型，导致EPL的风险。深井水和蔬菜，水果和动物肝脏的消耗与较低的EPL风险有关。本研究提出了一种完全不同的模式，酒精使用在EPL中仅发挥着次要作用，过度烟草使用显示了淮安区农村地区的重要关联，而饮食习惯和环境暴露可能是主导因素。这项工作可能很有希望提供科学证据，以支持该地区的ESCC初步预防。

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  • 来源
    《Cancer prevention research.》 |2019年第7期|共14页
  • 作者

    Pan Da; Su Ming; Zhang Ting; Miao Caiyun; Fu Lingmeng; Yang Ligang; Song Guang; Raine Philip J.; Wang Shaokang; Sun Guiju;

  • 作者单位

    Southeast Univ Minist Educ Key Lab Environm Med &

    Engn Nanjing Jiangsu Peoples R China;

    Huaian Dist Ctr Dis Control &

    Prevent Huaian Peoples R China;

    Southeast Univ Minist Educ Key Lab Environm Med &

    Engn Nanjing Jiangsu Peoples R China;

    Huaian Dist Ctr Dis Control &

    Prevent Huaian Peoples R China;

    Southeast Univ Minist Educ Key Lab Environm Med &

    Engn Nanjing Jiangsu Peoples R China;

    Southeast Univ Minist Educ Key Lab Environm Med &

    Engn Nanjing Jiangsu Peoples R China;

    Huaian Dist Ctr Dis Control &

    Prevent Huaian Peoples R China;

    Southeast Univ Minist Educ Key Lab Environm Med &

    Engn Nanjing Jiangsu Peoples R China;

    Southeast Univ Minist Educ Key Lab Environm Med &

    Engn Nanjing Jiangsu Peoples R China;

    Southeast Univ Minist Educ Key Lab Environm Med &

    Engn Nanjing Jiangsu Peoples R China;

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  • 中图分类 肿瘤学;
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