Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes

Krokowski Sina; Lobato-Marquez Damian; Chastanet Arnaud; Pereira Pedro Matos; Angelis Dimitrios; Galea Dieter; Larrouy-Maumus Gerald; Henriques Ricardo; Spiliotis Elias T.; Carballido-Lopez Rut; Mostowy Serge

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Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes

机译：Septins识别和诱捕分割的细菌细胞以供给溶酶体

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The cytoskeleton occupies a central role in cellular immunity by promoting bacterial sensing and antibacterial functions. Septins are cytoskeletal proteins implicated in various cellular processes, including cell division. Septins also assemble into cage-like structures that entrap cytosolic Shigella, yet how septins recognize bacteria is poorly understood. Here, we discover that septins are recruited to regions of micron-scale membrane curvature upon invasion and division by a variety of bacterial species. Cardiolipin, a curvature-specific phospholipid, promotes septin recruitment to highly curved membranes of Shigella, and bacterial mutants lacking cardiolipin exhibit less septin cage entrapment. Chemically inhibiting cell separation to prolong membrane curvature or reducing Shigella cell growth respectively increases and decreases septin cage formation. Once formed, septin cages inhibit Shigella cell division upon recruitment of autophagic and lysosomal machinery. Thus, recognition of dividing bacterial cells by the septin cytoskeleton is a powerful mechanism to restrict the proliferation of intracellular bacterial pathogens.

机译：细胞骨架通过促进细菌感测和抗菌功能来占据细胞免疫中的核心作用。 Septins是细胞骨架蛋白，其具有各种细胞过程，包括细胞分裂。 Septins还组装成类似的笼状结构，诱捕细胞溶质志贺氏菌，但Septins如何识别细菌是如何理解的。在这里，我们发现在侵袭和分开各种细菌物种时征集嵌入素对微米凝块曲率的区域。 CardionIpin，一种曲率特异性磷脂，促进SepIn募集到令人痛的高度弯曲膜，缺乏心肌蛋白的细菌突变体表现出较少的静止载体夹纸。化学抑制细胞分离以延长膜曲率或减少志贺氏菌细胞生长分别增加并降低静止笼形成。一旦形成，在募集自噬和溶酶体机械时，静止素笼抑制了志氏细胞分裂。因此，通过静止细胞骨架划分细菌细胞的识别是限制细胞内细菌病原体的增殖的强烈机制。

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《Cell Host & Microbe》 |2018年第6期|共13页
作者
Krokowski Sina; Lobato-Marquez Damian; Chastanet Arnaud; Pereira Pedro Matos; Angelis Dimitrios; Galea Dieter; Larrouy-Maumus Gerald; Henriques Ricardo; Spiliotis Elias T.; Carballido-Lopez Rut; Mostowy Serge;
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作者单位

Imperial Coll London Sect Microbiol MRC Ctr Mol Bacteriol &

Infect London SW7 2AZ England;

Imperial Coll London Sect Microbiol MRC Ctr Mol Bacteriol &

Infect London SW7 2AZ England;

Univ Paris Saclay AgroParisTech MICALIS INRA F-78350 Jouy En Josas France;

UCL MRC Lab Mol Cell Biol Quantitat Imaging &

NanoBiophys Grp London WC1E 6BT England;

Drexel Univ Dept Biol Philadelphia PA 19104 USA;

Imperial Coll London Sect Microbiol MRC Ctr Mol Bacteriol &

Infect London SW7 2AZ England;

Imperial Coll London Dept Life Sci MRC Ctr Mol Bacteriol &

Infect Fac Nat Sci London SW7 2AZ England;

UCL MRC Lab Mol Cell Biol Quantitat Imaging &

NanoBiophys Grp London WC1E 6BT England;

Drexel Univ Dept Biol Philadelphia PA 19104 USA;

Univ Paris Saclay AgroParisTech MICALIS INRA F-78350 Jouy En Josas France;

Imperial Coll London Sect Microbiol MRC Ctr Mol Bacteriol &

Infect London SW7 2AZ England;

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正文语种 eng
中图分类普通生物学;
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1. Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes [J] . Krokowski Sina, Lobato-Marquez Damian, Chastanet Arnaud, Cell Host & Microbe . 2018,第6期

机译：Septins识别和诱捕分割的细菌细胞以供给溶酶体
2. Entrapment of bacterial cellulose nanocrystals stabilized Pickering emulsions droplets in alginate beads for hydrophobic drug delivery [J] . Yan Huiqiong, Chen Xiuqiong, Feng Meixi, Colloids and Surfaces, B. Biointerfaces . 2019,第期

机译：捕获细菌纤维素纳米晶体稳定的酸盐乳液液体溶液中的脂肪酸珠疏水药物递送
3. Optimization of the entrapment of bacterial cell envelope extracts into microparticles for vaccine delivery [J] . MAITE ESTEVAN, CARLOS GAMAZO, GUSTAVO GONZALEZ-GAITANO Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres . 2006,第2期

机译：优化将细菌细胞包膜提取物截留到微粒中以进行疫苗输送
4. TARGETED LYSOSOME DISRUPTIVE ELEMENTS FOR THE IMPROVEMENT OF CELL SPECIFIC GENE DELIVERY [C] . Sabine M.W. van Rossenberg, Karen M. Sliedregt-Bol, Theo J.C. van Berkel, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：有针对性的溶酶体破坏性元素，用于改善细胞特异性基因的传递
5. Progress toward a combined bacterial and viral gene delivery system for mammalian cells. [D] . Simper, Melissa Sue. 2004

机译：面向哺乳动物细胞的细菌和病毒基因联合递送系统的进展。
6. Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes [O] . Sina Krokowski, Damián Lobato-Márquez, Arnaud Chastanet, -1

机译：Septins识别并捕获分离的细菌细胞以递送至溶酶体
7. The Molecularly Crowded Cytoplasm of Bacterial Cells: Dividing Cells Contrasted with Viable but Non-culturable (VBNC) Bacterial Cells [O] . 2013

机译：细菌细胞的分子拥挤细胞质：与可行但非培养（VBNC）细菌细胞的分割细胞对比

Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes

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