• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell motility and the cytoskeleton >Intermediate filaments in Caenorhabditis elegans.
【24h】

Intermediate filaments in Caenorhabditis elegans.

机译：中间细丝在Caenorhabditis elegans中。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intermediate filaments (IFs) make up one of the three major fibrous cytoskeletal systems in metazoans. Numerous IF polypeptides are synthesized in cell type-specific combinations suggesting specialized functions. The review concentrates on IFs in the model organism Caenorhabditis elegans which carries great promise to elucidate the still unresolved mechanisms of IF assembly into complex networks and to determine IF function in a living organism. In contrast to Drosophila melanogaster, which lacks cytoplasmic IFs altogether, the nematode genome contains 11 genes coding for cytoplasmic IFs and only a single gene for a nuclear lamin. Its cytoplasmic IFs are expressed in developmentally and spatially defined patterns. As an example we present the case of the intestinal IFs which are abundant in the mechanically resilient endotube, a prominent feature of the C. elegans intestinal terminal web region. This IF-rich structure brings together all three cytoskeletal filaments that are integrated into a coherent entity by the C. elegans apical junction (CeAJ) thereby completely surrounding and stabilizing the intestinal lumen with its characteristic brush border. Concepts on the developmental establishment of the endotube in relation to polarization and its function for maintenance of epithelial integrity are discussed. Furthermore, possible connections of the cytoplasmic cytoskeleton to the nuclear lamin IFs and the importance of these links for nuclear positioning are summarized.
机译：中间细丝（IFS）组成美人组织三种主要纤维细胞骨骼系统之一。如果在细胞类型特定组合中合成多肽，则暗示专门函数的组合。审查专注于IFS在模型生物中的IFS Caenorhabditis elegans，这承诺阐明仍然未解决的机制，如果组装到复杂的网络中，并确定是否在生物体中的功能。与果蝇的果蝇混合物相比，缺乏细胞质IFS的IFS，线虫基因组含有11个基因，编码细胞质IFS和仅用于核塑料的单个基因。其细胞质IFS在发育和空间定义的图案中表达。作为一个例子，我们呈现在机械弹性内嵌管中丰富的肠道IFS的情况，C.秀丽隐藏仪肠道绕线区域的突出特征。富含IF的结构将所有三个细胞骨架长丝一起融合到连贯的实体中，C.杆状杆状物顶点（CEAJ）完全围绕和稳定肠腔与其特征刷边界。讨论了与极化相关的内部管的发育建立的概念及其维持上皮完整性的功能。此外，总结了细胞质细胞骨架与核定位的核定位链接的可能性和对核定位联系的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号