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The hypothalamus and neuropsychiatric disorders: psychiatry meets microscopy

机译：下丘脑和神经精神疾病：精神病学符合显微镜

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摘要

The past decades have witnessed an explosion of knowledge on brain structural abnormalities in schizophrenia and depression. Focusing on the hypothalamus, we try to show how postmortem brain microscopy has contributed to our understanding of mental disease-related pathologic alterations of this brain region. Gross anatomical abnormalities (volume changes of the third ventricle, the hypothalamus, and its nuclei) and alterations at the cellular level (loss of neurons, increased or decreased expression of hypothalamic peptides such as oxytocin, vasopressin, corticotropin-releasing hormone, and other regulatory factors as well as of enzymes involved in neurotransmitter and neuropeptide metabolism) have been reported in schizophrenia and/or depression. While histologic research has mainly concentrated on neurons, little is currently known about the impact of non-neuronal cells for hypothalamus pathology in mental disorders. Their study would be a rewarding task for the future.
机译：过去几十年目睹了精神分裂症和抑郁症脑结构异常的知识爆发。 专注于下丘脑，我们试图展示后期脑显微镜如何为我们对这种大脑区域的精神疾病相关病理改变做出贡献的贡献。 细胞水平的总解剖异常（第三脑室，下丘脑和核的体积变化）和细胞水平的改变（神经元的丧失，下丘脑肽的表达增加或降低，如催产素，血管加压素，皮质素释放激素和其他调节 在精神分裂症和/或抑郁症中报道了因素以及参与神经递质和神经催化代谢的酶。 虽然组织学研究主要集中在神经元上，但目前关于非神经元细胞在精神障碍中的下丘脑病理学的影响很少。 他们的研究将是未来的一个有益的任务。

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