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首页> 外文期刊>Acta oncologica. >Particle species dependence of cell survival RBE: Evident and not negligible
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Particle species dependence of cell survival RBE: Evident and not negligible

机译:细胞存活的颗粒物依赖性RBE:明显且不可忽略

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摘要

With great interest we noticed the work of Singers Serensen, Overgaard and Bassler [1], where the authors question if the linear energy transfer (LET) of ion beams can serve as a unique parameter determining the relative biological effectiveness (RBE) of ion irradiation, neglecting the particular particle species. For this purpose the authors collected a set of in vitro cell survival data from the published literature and came to the conclusion that 'the influence of varying the particle type on the RBE was far from obvious, compared to the general experimental noise'. They further state in the abstract that '...a dependence of particle type cannot be concluded, and LET alone in fact does seem to be an adequate parameter for describing RBE at 10% survival'.
机译:我们非常感兴趣地注意到了Singers Serensen,Overgaard和Bassler [1]的工作,其中作者质疑离子束的线性能量转移(LET)是否可以作为确定离子辐照的相对生物有效性(RBE)的唯一参数。 ,忽略了特定的粒子种类。为此,作者从已发表的文献中收集了一组体外细胞存活数据,得出的结论是:“与普通实验噪声相比,改变颗粒类型对RBE的影响远不明显”。他们进一步在摘要中指出:“ ...无法得出颗粒类型的依赖性,事实上,仅LET确实是描述10%存活率的RBE的适当参数”。

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