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首页> 外文期刊>Cellular immunology >Biological activities of interleukin (IL)-21 in human monocytes and macrophages
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Biological activities of interleukin (IL)-21 in human monocytes and macrophages

机译：白细胞和巨噬细胞白细胞介素（IL）-21的生物活性

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The biological roles of interleukin (IL)-21 in human monocytes and macrophages have been neglected. We previously demonstrated that IL-21 induce phagocytosis and established that Syk is a new molecular target of IL-21. Herein, we found that IL-21 is not chemoattractant for immature THP-1 and primary monocytes but can increase the capacity of THP-1 cells (not primary monocytes) to adhere onto a cell substratum by a Syk-dependent mechanism without altering the expression of a panel of cell surface molecules. Unlike THP- 1 and monocytes, IL-21 can increase metalloproteinase (MMP)-9 secretion and activity in monocyte-derived macrophages (HMDM), as assessed by western blot and zymography experiments, respectively. We reported that IL-21 did not increase the production of IL-6 and the chemokines MIP-1 alpha and GRO-alpha in HMDM. Therefore, IL-21 can increase functions other that phagocytosis, but this cytokine does not have a large spectrum of biological activities in monocytes and macrophages.
机译：白细胞介素（IL）-21在人单核细胞和巨噬细胞中的生物学作用被忽略了。我们之前证明IL-21诱导吞噬作用并确定Syk是IL-21的新分子靶标。在此，我们发现IL-21不是Chemattractactor用于未成熟的THP-1和初级单核细胞，但可以通过Syk依赖性机制增加THP-1细胞（非初级单核细胞）的容量，而不会改变表达式细胞表面分子面板。与THP-1和单核细胞不同，IL-21分别可以增加单核衍生巨噬细胞（HMDM）中的金属蛋白酶（MMP）-9分泌和活性，分别由Western印迹和酶谱实验评估。我们报道，IL-21没有增加IL-6和趋化因子MIP-1α和Gro-alpha的产生。因此，IL-21可以增加其他吞噬作用的功能，但这种细胞因子在单核细胞和巨噬细胞中没有大谱的生物活性。

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