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首页> 外文期刊>Cellular immunology >Dendritic cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions.
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Dendritic cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions.

机译：树突状细胞响应于来自金黄色葡萄球菌感染的特征性皮炎病变的细菌产物产生炎性细胞因子。

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摘要

Atopic Dermatitis (AD) patients often acquire secondary skin infections resulting in increased inflammation. The increased inflammation occurs through the activation of multiple cell types including dendritic cells (DC). In this study, we investigated the activity of soluble products present in infected AD lesions by measuring the ability of patients' wash fluids from a quantitative culture of lesions to activate DC. We found that wash fluid derived from AD lesions induced cytokine production by murine bone marrow-derived DC, including IL-1beta, IL-6, IotaL-10, and tumor necrosis factor-alpha. The lipoprotein lipoteichoic acid (LTA) from Staphylococcusaureus was implicated as a potent stimulus in the wash fluids as only wash fluid samples that contained LTA exerted this activity, and exogenous LTA triggered similar DC cytokine activation. Wash fluid- and LTA-stimulated DC cytokine production required MyD88, but not the platelet-activating factor receptor (PAF-R), despite the ability of LTA to function through this receptor in keratinocytes. Thus, our results support a role for DC in the worsening of AD inflammation due to secondary bacteria infections.
机译：特应性皮炎（AD）患者经常获得继发性皮肤感染导致炎症增加。通过在包括树突细胞（DC）的多种细胞类型的激活来发生增加的炎症。在这项研究中，我们通过测量来自病变的定量培养的患者洗液的能力来研究感染的广告病变中的可溶性产品的活性。我们发现，从AD病变衍生的洗涤液通过鼠骨髓衍生的DC诱导细胞因子产生，包括IL-1Beta，IL-6，IOTA1-10和肿瘤坏死因子-α。来自葡萄球菌的脂蛋白脂蛋白酸（LTA）涉及洗涤液中的有效刺激，仅作为施加LTA的洗涤流体样品施加该活性，并且外源LTA触发了类似的DC细胞因子活化。尽管LTA在角质形成细胞中通过该受体能力能够，但是如血小板活化因子受体（PAF-R），所需的液体和LTA刺激的DC细胞因子产生。因此，我们的研究结果支持DC在患有次生细菌感染的广告炎症恶化中的作用。

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