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首页> 外文期刊>Cellular immunology >Dendritic cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions.
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Dendritic cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions.

机译：树突状细胞响应由金黄色葡萄球菌感染的特应性皮炎病变的细菌产物产生炎性细胞因子。

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摘要

Atopic Dermatitis (AD) patients often acquire secondary skin infections resulting in increased inflammation. The increased inflammation occurs through the activation of multiple cell types including dendritic cells (DC). In this study, we investigated the activity of soluble products present in infected AD lesions by measuring the ability of patients' wash fluids from a quantitative culture of lesions to activate DC. We found that wash fluid derived from AD lesions induced cytokine production by murine bone marrow-derived DC, including IL-1beta, IL-6, IotaL-10, and tumor necrosis factor-alpha. The lipoprotein lipoteichoic acid (LTA) from Staphylococcusaureus was implicated as a potent stimulus in the wash fluids as only wash fluid samples that contained LTA exerted this activity, and exogenous LTA triggered similar DC cytokine activation. Wash fluid- and LTA-stimulated DC cytokine production required MyD88, but not the platelet-activating factor receptor (PAF-R), despite the ability of LTA to function through this receptor in keratinocytes. Thus, our results support a role for DC in the worsening of AD inflammation due to secondary bacteria infections.
机译：特应性皮炎（AD）患者通常会获得继发性皮肤感染，从而导致炎症加剧。炎症增加是通过多种细胞类型（包括树突状细胞）的激活而发生的。在这项研究中，我们通过测量病灶定量培养物中患者洗液激活DC的能力，研究了感染AD病灶中存在的可溶性产物的活性。我们发现，源自AD病变的冲洗液可诱导鼠骨髓来源的DC产生细胞因子，包括IL-1beta，IL-6，IotaL-10和肿瘤坏死因子-α。来自葡萄球菌的脂蛋白脂蛋白酸（LTA）被认为是洗涤液中的一种强力刺激，因为只有含有LTA的洗涤液样品才发挥这种活性，而外源性LTA触发了类似的DC细胞因子活化。洗涤液和LTA刺激的DC细胞因子的产生需要MyD88，而血小板活化因子受体（PAF-R）则不需要，尽管LTA可以通过角质形成细胞中的该受体发挥功能。因此，我们的结果支持DC在由继发细菌感染引起的AD炎症恶化中的作用。

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