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首页> 外文期刊>Cell cycle >MiR-26b reverses temozolomide resistance via targeting Wee1 in glioma cells
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MiR-26b reverses temozolomide resistance via targeting Wee1 in glioma cells

机译：miR-26b通过胶质瘤细胞靶向WEE1反转替莫唑胺抗性

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摘要

Emerging evidence has demonstrated that microRNAs (miRNA) play a critical role in chemotherapy-induced epithelial-mesenchymal transition (EMT) in glioma. However, the underlying mechanism of chemotherapy-triggered EMT has not been fully understood. In the current study, we determined the role of miR-26b in regulation of EMT in stable temozolomide (TMZ)-resistant (TR) glioma cells, which have displayed mesenchymal features. Our results illustrated that miR-26b was significantly downregulated in TR cells. Moreover, ectopic expression of miR-26b by its mimics reversed the phenotype of EMT in TR cells. Furthermore, we found that miR-26b governed TR-mediate EMT partly due to governing its target Wee1. Notably, overexpression of miR-26b sensitized TR cells to TMZ. These findings suggest that upregulation of miR-26b or targeting Wee1 could serve as novel approaches to reverse chemotherapy resistance in glioma.
机译：新兴的证据表明，MicroRNA（miRNA）在化疗诱导的胶质瘤中的上皮 - 间充质转换（EMT）中起着关键作用。 然而，化疗触发的EMT的潜在机制尚未得到完全理解。 在目前的研究中，我们确定了miR-26b在稳定替替莫唑胺（TMZ） - 胶质瘤细胞中的调节中的作用，该细胞（TR）胶质瘤细胞展示了间充质特征。 我们的结果表明，MiR-26B在TR细胞中显着下调。 此外，其模仿MiR-26b的异位表达逆转了TR细胞中EMT的表型。 此外，我们发现MIR-26B定治了TR-MEDIATE EMT，部分原因是管理其目标WEE1。 值得注意的是，MiR-26b的过表达敏感的TR细胞至TMZ。 这些发现表明miR-26b或靶向wee1的上调可以作为逆转胶质瘤中化疗抗性的新方法。

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  • 来源
    《Cell cycle》 |2017年第20期|共11页
  • 作者

    Wang Lixia; Su Jingna; Zhao Zhe; Hou Yingying; Yin Xuyuan; Zheng Nana; Zhou Xiuxia; Yan Jingzhe; Xia Jun; Wang Zhiwei;

  • 作者单位

    Soochow Univ Cyrus Tang Hematol Ctr Suzhou Peoples R China;

    Soochow Univ Cyrus Tang Hematol Ctr Suzhou Peoples R China;

    Soochow Univ Cyrus Tang Hematol Ctr Suzhou Peoples R China;

    Soochow Univ Cyrus Tang Hematol Ctr Suzhou Peoples R China;

    Soochow Univ Cyrus Tang Hematol Ctr Suzhou Peoples R China;

    Soochow Univ Cyrus Tang Hematol Ctr Suzhou Peoples R China;

    Soochow Univ Cyrus Tang Hematol Ctr Suzhou Peoples R China;

    Jilin Prov Canc Hosp Dept Abdominal Oncosurg 1808 Huguang Rd Changchun Jilin Peoples R China;

    Bengbu Med Coll Dept Biochem &

    Mol Biol Bengbu Anhui Peoples R China;

    Soochow Univ Cyrus Tang Hematol Ctr Suzhou Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Glioma; growth; miR-26b; temozolomide; Wee1;

    机译：胶质瘤;生长;miR-26b;替莫唑胺;wee1;

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