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Move over: DLIC-like protein in pole position in meiosis.

机译:转移:在减数分裂中的极点位置的DLIC样蛋白质。

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摘要

In a previous issue of Cell Cycle,' Cornelia Rumpf and colleagues report their discovery of dill1 a novel gene in fission yeast required for chromosome segregation in meiosis. In meiosis, one round of DNA replication is followed by two successive rounds of chromosome segregation (meiosis I and meiosis II), generating haploid gametes from diploid precursor cells. Among a number of fundamental differences between mitosis and meiosis (reviewed in ref. 2), recombination in meiosis is used to provide a physical connection between homologous chromosomes, which ensures their correct segregation. During meiosis I, homologous chromosomes (each consisting of two sister chromatids) locate each other, pair and recombine during an extended prophase. Homologous chromosomes are then segregated to opposite poles while sister chromatids remain physically attached through meiosis-specific cohesion. Pairing of homologous chromosomes is important for homologous recombination, and both events contribute to the accurate segregation of chromosomes during meiosis.
机译:在先前的细胞周期问题中,'Cornelia Rumpf及其同事报告了他们在裂变酵母中发现了DILL1一种新型基因在减数分裂中染色体偏析所需的裂变酵母中。在减数分裂中,一轮DNA复制之后是两个连续的两轮染色体隔离(MeIosis I和Meiosis II),从二倍体前体细胞产生单倍体配子。在有丝分裂和减数分裂之间的许多基本差异中(在参考文献中审查)中,使用体重减出的重组来提供同源染色体之间的物理连接,这确保了它们的正确偏析。在减数分裂时,I,同源染色体(各自由两个姐妹染色体组成)彼此定位,对在延长的预先存在期间对和重组。然后将同源染色体分离成相对的杆,而乳腺染色体仍然通过细胞异形特异性内粘性物理连接。同源染色体的配对对于同源重组是重要的,并且这两个事件都有助于减少染色体的准确偏析。

著录项

  • 来源
    《Cell cycle》 |2010年第11期|共1页
  • 作者

    Clyne RK;

  • 作者单位

    Institute of Technology Tallaght Dublin Ireland.;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

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