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首页> 外文期刊>Cell cycle >Pathogenic DNA: cytosolic DNA promotes inflammation in psoriasis.
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Pathogenic DNA: cytosolic DNA promotes inflammation in psoriasis.

机译：致病DNA：细胞溶质DNA促进牛皮癣中的炎症。

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摘要

In 1944, DNA was characterized as the carrier for genetic information. The ultra-structure of DNA and the mechanisms of gene duplication during cell division were subsequently uncovered in 1953 by Watson, Crick and others. Over decades' research on DNA then primarily focused on how genetic information was encoded, conserved and passed on. Unexpectedly, an additional, non-informative role of nucleic acids was discovered around the turn of the century: foreign nucleic acids derived from pathogens were identified as molecular patterns which could be sensed by the host in bacterial or viral infections. Pathogen-derived DNA or RNA is internalized by specialized host immune cells and detected within the endosomal compartments by membrane-bound toll-like receptors (TLRs 3, 7, 8 and 9). TLRs then initiate an innate immune response leading to the secretion of type I inter-ferons and proinflammatory cytokines.
机译：1944年，DNA的特征是遗传信息的载体。 随后于1953年由Watson，Crick等人分别发现了DNA的超结构和细胞分裂中的基因复制机制。 多十年来，DNA的研究随后主要专注于如何编码遗传信息，保守和通过。 出乎意料地，在世纪之交围绕世纪之交发现了核酸的另外，不受信息的作用：衍生自病原体的外核酸被鉴定为分子模式，其可以通过细菌或病毒感染中的宿主感测。 通过专用宿主免疫细胞内化病原体衍生的DNA或RNA，并通过膜结合的Toll样受体（TLR 3,7,8和9）在内体间隔内检测。 然后TLRS发起先天免疫应答，导致I型融合型和促炎细胞因子的分泌。

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