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首页> 外文期刊>Chemical Senses >Neuropeptide S Displays as a Key Neuromodulator in Olfactory Spatial Memory
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Neuropeptide S Displays as a Key Neuromodulator in Olfactory Spatial Memory

机译：神经肽S显示为嗅觉空间记忆中的关键神经调节剂

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摘要

Neuropeptide S (NPS) is an endogenous peptide recently recognized to be presented in the brainstem and believed to play an important role in maintaining memory. The deletion of NPS or NPS receptor (NPSR) in mice shows a deficit in memory formation. Our recent studies have demonstrated that central administration of NPS facilitates olfactory function and ameliorates olfactory spatial memory impairment induced by muscarinic cholinergic receptor antagonist and N-methyl-(D)-aspartate receptor antagonist. However, it remains to be determined if endogenous NPS is an indispensable neuromodulator in the control of the olfactory spatial memory. In this study, we examined the effects of NPSR peptidergic antagonist [D-Val(5)]NPS (10 and 20 nmol, intracerebroventricular) and nonpeptidergic antagonist SHA 68 (10 and 50 mg/kg, intraperitoneal) on the olfactory spatial memory using computer-assisted 4-hole-board olfactory spatial memory test in mice. Furthermore, immunofluorescence was employed to identify the distributions of c-Fos and NPSR immunoreactive (-ir) neurons in olfactory system and hippocampal formation known to closely relate to the olfactory spatial memory. [D-Val(5)]NPS dosing at 20 nmol and SHA 68 dosing at 50 mg/kg significantly decreased the number of visits to the 2 odorants interchanged spatially, switched odorants, in recall trial, and simultaneously reduced the percentage of Fos-ir in NPSR-ir neurons, which were densely distributed in the anterior olfactory nucleus, piriform cortex, subiculum, presubiculum, and parasubiculum. These findings suggest that endogenous NPS is a key neuromodulator in olfactory spatial memory.
机译：神经肽S（NPS）是最近认识到脑干中的内源性肽并认为在维持记忆中发挥重要作用。小鼠中NPS或NPS受体（NPSR）的缺失显示了内存形成的缺陷。我们最近的研究表明，NPS的中央管理促进嗅觉功能，并改善由肌肉胆碱能受体拮抗剂和N-甲基 - （D） - 海地受体拮抗剂诱导的嗅觉空间记忆障碍。然而，如果内源NPS是控制嗅觉空间记忆的不可缺少的神经调节剂，则仍有待确定。在这项研究中，我们研究了NPSR Peptivergic拮抗剂[D-Val（5）] NPS（10和20nmol，脑室内腔内）和非分裂拮抗剂SHA 68（10和50mg / kg，腹膜内）使用的影响小鼠的计算机辅助4孔板嗅觉空间内存试验。此外，使用免疫荧光来鉴定嗅觉系统中C-FOS和NPSR免疫反应（-Ir）神经元的分布，并已知与嗅觉空间记忆密切相关的海马形成。 [D-Val（5）]在50mg / kg的20nmol和SHA 68给药的NPS给药显着降低了在空间，切换的气味剂，在召回试验中互换的2个气味剂的次数，并同时降低了FOS-的百分比IR在NPSR-IR神经元中，其浓密地分布在前嗅核，粒状皮质，亚细胞，序列和寄生症中。这些发现表明内源性NPS是嗅觉空间记忆中的关键神经调节剂。

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  • 来源
    《Chemical Senses》 |2020年第3期|共8页
  • 作者

    Wang Can; Xin Le; Cai Chen-Chen; Cong Chao-Yu; Xie Jun-Fan; Kong Xiang-Pan; Dong Chao-Yu; Li Jing; Cui Guang-Fu; Chen Hai-Lin; Ren Yan-Li; Shao Yu-Feng; Hou Yi-Ping;

  • 作者单位

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

    Lanzhou Univ Sch Basic Med Sci Dept Neurosci Key Lab Preclin Study New Drugs Gansu Prov 199 Donggang Xi Rd Lanzhou 730000 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生理学;
  • 关键词

    antagonist; c-Fos; neuropeptide S; neuropeptide S receptor; olfactory spatial memory;

    机译：拮抗剂;C-FOS;神经肽S;神经肽的受体;嗅觉空间记忆;

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