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首页> 外文期刊>Chemicke Zvesti >Chemical characterization, antimicrobial activity, and cytotoxic activity of Mikania micrantha Kunth flower essential oil from North East India
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Chemical characterization, antimicrobial activity, and cytotoxic activity of Mikania micrantha Kunth flower essential oil from North East India

机译：西北部西北部Mikania Micrantha Kunth花精油的化学表征，抗微生物活性和细胞毒性活性

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摘要

Mikania micrantha Kunth (mile-a-minute) is a major invasive weed with medicinal properties. It causes destruction of forests and threat to crop plantations, thus affecting the agriculture-based economy of a country. As an attempt to mitigate this problem, we have studied the applicability of M. micrantha flower essential oil against disease causing microorganisms and inhibition of cancerous cells. Sixty-six compounds were characterized from the flower essential oil by gas chromatography- mass spectrometry. The major constituents were: Isoledene (16%), δ-Cadinene (11.2%), Debromofiliformin (9.4%), Trans-Caryophyllene (9.1%), β-Bisabolene (7.4%), Germacrene-D (5.8%), and Zingiberene (5.3%). The oil is a complex mixture containing mainly sesquiterpene hydrocarbons (62.9%) and oxygenated sesquiterpenes (23.9%) with the other terpene compounds. Well-diffusion and resazurin assay were conducted to determine antimicrobial activity and minimum inhibitory concentration (MIC) of the essential oil. Flower oil showed best activity against Mycobacterium smegmatis and Candida albicans with MIC 8 μg/mL. Moreover, it is the first report of antimicrobial activity of the oil towards M. smegmatis, C. albicans, Staphylococcus aureus, and Pseudomonas aeruginosa. Minimum bactericidal and fungicidal concentration was determined and mechanism of antimicrobial activity was investigated by Field Emission-Scanning Electron Microscopy and Transmission Electron Microscopy analysis. It is the first cytotoxicity report of M. micrantha flower essential oil for cervical, ovarian, and pancreatic cancer cell lines. Through MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, we have found that oil has excellent cytotoxicity against HeLa cervical cancer cell lines ( IC_(50) 5.44 ± 1.33 μg/mL) and PA1 ovarian cancer cell lines ( IC_(50)10.57 ± 1.44 μg/mL). The essential oil extracted from the invasive weed M. micrantha flower is now found to have antimicrobial and anticancer
机译：Mikania Micrantha Kunth（英里一分钟）是一种具有药物性质的主要侵略性杂草。它会导致破坏森林和对作物种植园的威胁，从而影响一个国家的农业。作为减轻这个问题的尝试，我们研究了M.Mirtha花精油对疾病的适用性，导致微生物和癌细胞的抑制。通过气相色谱 - 质谱法从花精油表征六十六种化合物。主要成分为：癸烯（16％），δ-起级丁烯（11.2％），Debromofilificin（9.4％），反式羧基（9.1％），β-双硼烯（7.4％），GermacRene-D（5.8％），和Zingiberene（5.3％）。该油是一种复杂的混合物，主要含有倍半萜烯烃（62.9％）和含氧的倍半萜（23.9％），其它萜烯化合物。进行良好的扩散和脱氮素测定以确定精油的抗微生物活性和最小抑制浓度（MIC）。花油显示出对麦考杆菌和念珠菌与麦克风的最佳活动，MIC8μg/ ml。此外，它是朝向M.Smegmatis，C. albicans，金黄色葡萄球菌和假单胞菌铜绿假单胞菌的抗菌活性的第一报告。测定了最小杀菌和杀真菌浓度，通过现场排放扫描电子显微镜和透射电子显微镜分析研究了抗微生物活性机理。它是宫颈，卵巢和胰腺癌细胞系M. micrantha花精油的第一种细胞毒性报告。通过MTT（3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓溴化物）测定，我们发现油对Hela宫颈癌细胞系具有优异的细胞毒性（IC_（50）5.44±1.33μg/ ml）和PA1卵巢癌细胞系（IC_（50）10.57±1.44μg/ ml）。现在发现从侵入性杂草M. micrantha花中提取的精油具有抗微生物和抗癌

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  • 来源
    《Chemicke Zvesti》 |2020年第8期|共14页
  • 作者

    Snigdha Saikia; Kashyap J. Tamuli; Bardwi Narzary; Dipanwita Banik; Manobjyoti Bordoloi;

  • 作者单位

    Chemical Science and Technology Division CSIRNorth East Institute of Science and Technology Jorhat Assam 785006 India;

    Chemical Science and Technology Division CSIRNorth East Institute of Science and Technology Jorhat Assam 785006 India;

    Chemical Science and Technology Division CSIRNorth East Institute of Science and Technology Jorhat Assam 785006 India;

    Medicinal Aromatic and Economical Plants Group CSIR-North East Institute of Science and Technology Jorhat Assam 785006 India;

    Chemical Science and Technology Division CSIRNorth East Institute of Science and Technology Jorhat Assam 785006 India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

    GC-MS; Mikania micrantha; Essential oil; Antimicrobial; Cytotoxicity; SEM-TEM analysis;

    机译：GC-MS;Mikania Micrantha;精油;抗菌;细胞毒性;SEM-TEM分析;

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