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首页> 外文期刊>Acta Histochemica: Zeitschrift fur Histologische Topochemie >Morphological changes and patterns of ecdysone receptor B1 immunolocalization in the anterior silk gland undergoing programmed cell death in the silkworm, Bombyx mori.
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Morphological changes and patterns of ecdysone receptor B1 immunolocalization in the anterior silk gland undergoing programmed cell death in the silkworm, Bombyx mori.

机译：蚕蜕皮中蜕皮激素受体B1免疫定位的形态变化和模式在家蚕中受到程序性细胞死亡。

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摘要

The silk gland is a specific larval tissue of Lepidopteran insects and begins to degenerate shortly before pupation. The steroid hormone ecdysone triggers the stage specific programmed cell death of the anterior silk glands during metamorphosis in the silkworm, Bombyx mori. The anterior silk gland expresses ecdysone receptors, which are involved in regulation processes in response to ecdysone. In this study, the morphological changes, immunohistochemical localization and protein levels of ecdysone receptor B1 (EcR-B1) in the anterior silk gland of B. mori were investigated during programmed cell death. Morphological changes observed during the degeneration process involve the appearance of large vacuoles, probably autophagic vacuoles, which increase in number in pupal anterior silk glands. No macrophages were found in the silk gland during the prepupal and pupal stage unlike in apoptosis, which strongly suggests that programmed cell death of the anterior silk gland is carried out by autophagy. Morphological changes of the silk glands were accompanied by changes in the immunolocalization and protein levels of EcR-B1. The differences in tissue distribution and protein levels of EcR-B1 during the programmed cell death indicate that the receptor plays a major role in the modulation and function of ecdysone activity in Bombyx anterior silk glands. Our results indicate that EcR-B1 expression may be important for the process of programmed cell death in the anterior silk glands.
机译：丝腺是鳞翅目昆虫的一种特殊幼虫组织，在化ation之前不久就开始退化。类固醇激素蜕皮激素在家蚕变态过程中触发前丝腺的特定阶段程序性细胞死亡。前丝腺表达蜕皮激素受体，其参与对蜕皮激素的调节过程。在这项研究中，在程序性细胞死亡过程中调查了桑蚕前丝腺中蜕皮激素受体B1（EcR-B1）的形态变化，免疫组化定位和蛋白质水平。在变性过程中观察到的形态学变化涉及出现大的液泡，可能是自噬液泡，其在in前丝腺中的数量增加。与凋亡不同，在pu前和p期未在丝腺中发现巨噬细胞，这强烈表明前丝腺的程序性细胞死亡是通过自噬进行的。丝腺的形态变化伴随着EcR-B1的免疫定位和蛋白质水平的变化。程序性细胞死亡过程中EcR-B1的组织分布和蛋白质水平的差异表明，该受体在Bombyx前丝腺中的蜕皮激素活性的调节和功能中起主要作用。我们的结果表明，EcR-B1表达对于前丝腺中程序性细胞死亡的过程可能很重要。

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