The Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from Streptomyces sp.and Their Related Substances

Akiko Shimbashi; Ayako Tsuchiya; Masaya Imoto; Shigeru Nishiyama

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The Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from Streptomyces sp.and Their Related Substances

机译：吡喃萘喹啉衍生物的合成与生物活性来自链霉菌SP.ANAR相关物质

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The total synthesis of a novel pyranonaphthoquinone(2)having Cdc25A phosphatase inhibitory activity is achieved.The key step in this synthetic pathway is the intramolecular Michael addition for construction of the pyran ring system.The inhibitory activity of several derivatives,readily obtained from synthetic intermediates of 2,is assessed.The resulting data indicates that the pyran ring moiety is not a crucial factor for the activity.

机译：实现了具有CDC25A磷酸酶抑制活性的新型吡喃萘醌（2）的总合成。该合成途径的关键步骤是用于构建吡喃环系统的分子内迈克尔添加。几种衍生物的抑制活性，从合成中间体中容易获得在2中，评估所得数据表明吡喃环部分不是活动的关键因素。

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《Bulletin of the Chemical Society of Japan》 |2004年第10期|共6页
作者
Akiko Shimbashi; Ayako Tsuchiya; Masaya Imoto; Shigeru Nishiyama;
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Department of Chemistry Faculty of Science and Technology Keio University Hiyoshi 3-14-1 Kohoku-ku Yokohama 223-8522;

Department of Biosciences and Informatics Faculty of Science and Technology Keio University Hiyoshi 3-14-1 Kohoku-ku Yokohama 223-8522;

Department of Biosciences and Informatics Faculty of Science and Technology Keio University Hiyoshi 3-14-1 Kohoku-ku Yokohama 223-8522;

Department of Chemistry Faculty of Science and Technology Keio University Hiyoshi 3-14-1 Kohoku-ku Yokohama 223-8522;

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机译：吡喃萘喹啉衍生物的合成与生物活性来自链霉菌SP.ANAR相关物质
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The Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from Streptomyces sp.and Their Related Substances

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