Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer-Combined Analysis of the PORTEC Cohorts

Stelloo Ellen; Nout Remi A.; Osse Elisabeth M.; Juergenliemk-Schulz Ina J.; Jobsen Jan J.; Lutgens Ludy C.; van der Steen-Banasik Elzbieta M.; Nijman Hans W.; Putter Hein; Bosse Tjalling; Creutzberg Carien L.; Smit Vincent T. H. B. M.

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Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer-Combined Analysis of the PORTEC Cohorts

机译：通过将分子和临床病理因子集成在早期子宫内膜癌综合分析中的分子和临床病理因子来改善风险评估

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Purpose: Recommendations for adjuvant treatment for women with early-stage endometrial carcinoma are based on clinicopathologic features. Comprehensive genomic characterization defined four subgroups: p53-mutant, microsatellite instability (MSI), POLE-mutant, and no specific molecular profile (NSMP). We aimed to confirm the prognostic capacity of these subgroups in large randomized trial populations, investigate potential other prognostic classifiers, and integrate these into an integrated molecular risk assessment guiding adjuvant therapy.

机译：目的：提出早期子宫内膜癌患者的辅助治疗的建议是基于临床病理学特征。综合基因组表征定义了四个亚组：P53-突变体，微卫星不稳定性（MSI），极突变体，没有特定的分子曲线（NSMP）。我们的旨在确认这些亚组在大型随机试验群体中的预后能力，调查潜在的其他预后分类器，并将这些含量整合到综合分子风险评估引导佐剂治疗中。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2016年第16期|共10页
作者
Stelloo Ellen; Nout Remi A.; Osse Elisabeth M.; Juergenliemk-Schulz Ina J.; Jobsen Jan J.; Lutgens Ludy C.; van der Steen-Banasik Elzbieta M.; Nijman Hans W.; Putter Hein; Bosse Tjalling; Creutzberg Carien L.; Smit Vincent T. H. B. M.;
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作者单位

Leiden Univ Med Ctr Dept Pathol Leiden Netherlands;

Leiden Univ Med Ctr Dept Med &

Radiat Oncol Leiden Netherlands;

Leiden Univ Med Ctr Dept Pathol Leiden Netherlands;

Univ Med Ctr Utrecht Dept Radiat Oncol Utrecht Netherlands;

Med Spectrum Twente Dept Radiotherapy Enschede Netherlands;

MAASTtricht Radiat Oncol Clin Maastricht Netherlands;

Arnhems Radiotherapeut Inst Arnhem Netherlands;

Univ Groningen Univ Med Ctr Groningen Dept Obstet &

Gynaecol Groningen Netherlands;

Leiden Univ Med Ctr Dept Med Stat &

Bioinformat Leiden Netherlands;

Leiden Univ Med Ctr Dept Med &

Radiat Oncol Leiden Netherlands;

Leiden Univ Med Ctr Dept Med &

Radiat Oncol Leiden Netherlands;

Leiden Univ Med Ctr Dept Pathol Leiden Netherlands;

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正文语种 eng
中图分类肿瘤学;
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1. Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer-Combined Analysis of the PORTEC Cohorts [J] . Stelloo Ellen, Nout Remi A., Osse Elisabeth M., Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第16期

机译：通过将分子和临床病理因子集成在早期子宫内膜癌综合分析中的分子和临床病理因子来改善风险评估
2. Clinicopathological risk factors for pelvic lymph node metastasis in clinical early-stage endometrioid endometrial adenocarcinoma [J] . ZhangC., WangC., FengW. International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2012,第8期

机译：临床早期子宫内膜样子宫内膜腺癌盆腔淋巴结转移的临床病理危险因素
3. Postoperative Pelvic Radiotherapy in Patients With Endometrial Cancer May Increase the Risk for Secondary Pelvic Cancers: A Post Hoc Analysis of Results From the TME, PORTEC-1, and PORTEC-2 Trials [J] . Wissing Michel D., Azoulay Laurent Journal of Clinical Oncology . 2017,第16期

机译：患有子宫内膜癌患者的术后骨盆放疗可能会增加继发性骨盆癌症的风险：TME，PORTEC-1和PORTEC-2试验结果的后HOC分析
4. Integration of capacity factors analysis risk methodology and Ostrom's social ecological system assessment framework to assess and improve domestic water infrastructure in Nalgonda District, Andhra Pradesh, India [C] . Pailla Siddhartha, Louis Garrick 2011 IEEE Systems and Information Engineering Design Symposium . 2011

机译：整合能力因素分析风险方法和Ostrom的社会生态系统评估框架，以评估和改善印度安得拉邦纳尔贡达区的生活用水基础设施
5. Motivation for Substance Use, Venue of Sexual Encounter, and Sexual Risk Behavior among Men who Have Sex with Men (MSM) in the Multicenter AIDS Cohort Study (MACS): Factor Analysis, and Global vs. Event-Level Generalized Linear Mixed Model (GLMM) Assessment Approach. [D] . Burrell, Earl Ryan. 2014

机译：多中心艾滋病队列研究（MACS）中男男性接触者的物质使用动机，性遭遇场所和性风险行为：因素分析以及全球性与事件级广义线性混合模型（GLMM））评估方法。
6. Ten-year results of the PORTEC-2 trial for high-intermediate risk endometrial carcinoma: improving patient selection for adjuvant therapy [O] . B. G. Wortman, C. L. Creutzberg, H. Putter, 2018

机译：PORTEC-2高中风险子宫内膜癌试验的十年结果：改善辅助治疗的患者选择
7. Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer-Combined Analysis of the PORTEC Cohorts [O] . Stelloo, Ellen, Nout, Remi A., Osse, Elisabeth M., 2016

机译：通过整合早期子宫内膜癌的分子和临床病理因素改善风险评估-PORTEC人群的综合分析
8. Molecular Epidemiology of Breast Cancer: Establishment of an at Risk Cohort and Methods to Improve the Collection and Use of Risk Factor Data [R] . Johnson, C. C. 2000

机译：乳腺癌的分子流行病学：建立风险队列和改善风险因素数据收集和使用的方法

Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer-Combined Analysis of the PORTEC Cohorts

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