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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Use of Transcranial Direct Stimulation in the Treatment of Negative Symptoms of Schizophrenia
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Use of Transcranial Direct Stimulation in the Treatment of Negative Symptoms of Schizophrenia

机译：经颅直接刺激治疗精神分裂症的阴性症状

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摘要

Schizophrenia is a debilitating disease that affects approximately 1% of the population. Negative symptoms are among the major determinants of the functional impairment and a significant proportion of patients with negative symptoms will continue to experience these symptoms despite antipsychotic medications. There are promising results in the application of brain stimulation, particularly transcranial direct current stimulation (tDCS), for the reduction of negative symptoms of schizophrenia. However, findings are still controversial. This is a selective review of the literature published between 2011 and 2017 on use of tDCS in treatment of negative symptoms of schizophrenia. We included only randomized controlled trials where schizophrenia and negative symptoms were assessed using any psychometrically validated scale (eg, Positive and Negative Symptoms Scale or Scale for the Assessment of Negative Symptoms). Studies of participants with neurological conditions were excluded, as were those that did not report any symptom outcome variables. Only 5 studies are included. Three studies showed a decrease of negative symptoms. The other studies did not show any therapeutic effects of tDCS in the severity of positive and negative symptoms compared to controls. Our findings suggest that negative symptoms in schizophrenia can be treated with tDCS over the dorsolateral prefrontal cortex, but results are affected by several factors, such as the electrode montage, the concomitant medication, the homogeneity of the sample, the intensity of the tDCS treatment. Further randomized, double-blinded, sham-controlled studies in large samples are still needed to establish the effectiveness of the tDCS in the treatment of negative symptoms in schizophrenia, but there is the potential for tDCS to become a useful complementary treatment option in this population.
机译：精神分裂症是一种衰弱的疾病，影响大约1％的人口。消极症状是功能性损伤的主要决定因素，并且尽管抗精神病药物，但仍将在患有阴性症状的患者的大部分患者中继续进行这些症状。有希望在脑刺激的应用中，特别是经颅导流刺激（TDC）的应用，减少精神分裂症的阴性症状。但是，调查结果仍然存在争议。这是对2011年至2017年间发表的文献的选择性审查，用于在治疗精神分裂症的消极症状中使用TDC。我们仅包括随机对照试验，使用任何精神度验证的尺度评估精神分裂症和阴性症状（例如，阳性和阴性症状规模或评估消极症状的规模）。排除了对神经病症的参与者的研究，而那些没有报告任何症状结果变量的研究。只有5项研究。三项研究表明阴性症状减少。与对照相比，其他研究没有显示TDC在积极和阴性症状严重程度中的任何治疗效果。我们的研究结果表明，精神分裂症中的阴性症状可以在背侧前额叶皮质上用TDC治疗，但结果受到几个因素的影响，例如电极蒙太奇，伴随药物，样品的均匀性，TDCs治疗的强度。在大型样品中进一步随机，双盲，假手段研究仍然需要建立TDC在精神分裂症中的阴性症状治疗阴性症状的有效性，但TDC有可能成为该人群中有用的互补治疗选择。

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