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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Change in Quantitative EEG Theta Cordance as a Potential Predictor of Repetitive Transcranial Magnetic Stimulation Clinical Outcome in Major Depressive Disorder
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Change in Quantitative EEG Theta Cordance as a Potential Predictor of Repetitive Transcranial Magnetic Stimulation Clinical Outcome in Major Depressive Disorder

机译：定量脑电图的变化作为主要抑郁症中重复颅磁刺激临床结果的潜在预测因子

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Repetitive transcranial magnetic stimulation (rTMS) has demonstrated efficacy in major depressive disorder (MDD), although clinical outcome is variable. Change in the resting-state quantitative electroencephalogram (qEEG), particularly in theta cordance early in the course of treatment, has been linked to antidepressant medication outcomes but has not been examined extensively in clinical rTMS. This study examined change in theta cordance over the first week of clinical rTMS and sought to identify a biomarker that would predict outcome at the end of 6 weeks of treatment. Clinically stable outpatients (n = 18) received nonblinded rTMS treatment administered to the dorsolateral prefrontal cortex (DLPFC). Treatment parameters (site, intensity, number of pulses) were adjusted on an ongoing basis guided by changes in symptom severity rating scale scores. qEEGs were recorded at pretreatment baseline and after 1 week of left DLPFC (L-DLPFC) rTMS using a 21-channel dry-electrode headset. Analyses examined the association between week 1 regional changes in theta band (4-8 Hz) cordance, and week 6 patient- and physician-rated outcomes. Theta cordance change in the central brain region predicted percent change in Inventory of Depressive Symptomology–Self-Report (IDS-SR) score, and improvement versus nonimprovement on the Clinical Global Impression–Improvement Inventory (CGI-I) ( R ~(2)= .38, P = .007; and Nagelkerke R ~(2)= .78, P = .0001, respectively). The cordance biomarker remained significant when controlling for age, gender, and baseline severity. Treatment-emergent change in EEG theta cordance in the first week of rTMS may predict acute (6-week) treatment outcome in MDD. This oscillatory synchrony biomarker merits further study in independent samples.
机译：尽管临床结果是可变的，但重复的经颅磁刺激（RTMS）已经证明了主要抑郁症（MDD）的疗效。在治疗过程中早期的静静态定量脑电图（QEEG）的变化，特别是在θCodance中，已与抗抑郁药物结果有关，但尚未在临床rtms中进行广泛检查。本研究在临床RTMS的第一周检查了Theta Cordance的变化，并试图鉴定鉴定生物标志物，该生物标志物预测治疗6周结束的结果。临床稳定的门诊剂（n = 18）接受给施用于背侧前额外皮层（DLPFC）的非粘土RTMS处理。在持续的基础上通过症状严重程度评分评级分数的变化来调整治疗参数（站点，强度，脉冲数）。 Qeegs在预处理基线和左侧DLPFC（L-DLPFC）RTM的1周后记录，使用21通道干电极耳机。分析审查了第1周之间的关联在第1周的区域变化（4-8 Hz）Cordance，以及第6周的患者和医生评级结果。中央脑区的CORDANCE变化预测了抑郁症组族 - 自我报告（IDS-SR）评分库存的变化百分比，改善与临床全球印象改善库存（CGI-I）的改善（R〜（2） = .38，p = .007;和nagelkerke r〜（2）= .78，p = .0001）。在控制年龄，性别和基线严重程度时，Cordance Biomarker仍然是显着的。在RTMS的第一周eegθceegacordance的治疗肠道变化可以预测MDD中的急性（6周）治疗结果。这种振荡同步生物标志物优异的在独立样品中进一步研究。

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