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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Association Between Pathology and Electroencephalographic Activity in Parkinson’s Disease
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Association Between Pathology and Electroencephalographic Activity in Parkinson’s Disease

机译：帕金森病病理学与脑电图活动之间的关联

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Introduction . The key mechanisms that connect Parkinson’s disease pathology with dementia are unclear. We tested the hypothesis that the quantitative spectral electroencephalographic measure, delta bandpower, correlates with Lewy type synucleinopathy on pathological examination in Parkinson’s disease. As a corollary hypothesis, we analyzed whether there would be delta bandpower electroencephalographic differences between Parkinson’s disease dementia cases with and without pathological criteria for Alzheimer’s disease. Methods . We used pathological examination results from 44 Parkinson’s disease subjects from our brain bank with various degrees of cognitive decline, who had undergone electroencephalography. Pathological grading for Lewy type synucleinopathy, plaques, tangles, and indications of vascular pathology in subcortical and cortical areas were correlated with the most associated electroencephalographic biomarker with Parkinson’s disease dementia in our laboratory, delta bandpower. Group differences for all spectral electroencephalographic measures were also analyzed between cases with and without pathological criteria for Alzheimer’s disease. Results . Findings revealed significant correlations between delta bandpower with Lewy type synucleinopathy, whereas indications of Alzheimer’s disease or vascular pathology had nonsignificant correlation. The strongest association was with delta bandpower and Lewy type synucleinopathy in the anterior cingulate region. Mean delta bandpower was higher in the group for Parkinson’s disease dementia with Alzheimer’s disease pathology criteria than without. Conclusions . Lewy type synucleinopathy severity appears to be more associated with increased delta bandpower than with Alzheimer’s disease pathology or indications of vascular pathology over all cases. However, the presence of Alzheimer’s pathology may associate with more cortex physiological disruption in a subset of cases.
机译：介绍 。将帕金森病病理与痴呆症的关键机制尚不清楚。我们测试了定量光谱脑电图测量，Delta Bandpower，与Lewy型突触核苷病相关性关于帕金森病的病理检查的假设。作为一种推论假设，我们分析了帕金森病痴呆病例与阿尔茨海默病的病理标准之间是否存在达斯塔氏病毒脑电图差异。方法 。我们使用了来自我们脑库的44个帕金森病受试者的病理检查结果，具有各种认知下降，他们经历了脑电图。石油型突触核苷病的病理学分级，皮质和皮质区域血管病理学的斑块，缠结和迹象与我们在我们的实验室，Delta Bandpower中的帕金森病痴呆症的最相关的脑电图生物标志物相关。在Alzheimer疾病的病例和没有病理标准的情况下，还分析了所有光谱脑电图措施的组差异。结果 。调查结果显示Delta BandPower与Lewy型突触核苷酸病变之间的显着相关性，而阿尔茨海默病或血管病理学的指示具有无显着的相关性。最强大的关联是在前铰接区域中具有三角体带球和Lewy型突触核素病变。对于帕金森病痴呆，具有阿尔茨海默病病理学标准的帕金森病痴呆症的平均delta Bandpower比没有。结论。 Lewy型突触核苷病严重程度似乎与随着Alzheimer的疾病病理或血管病理学的适应症在所有情况下，与Alzheimer疾病病理或血管病理学的适应性更相关。然而，阿尔茨海默氏症病理的存在可能在病例子集中与更多的皮质生理破坏相关联。

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