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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >The Three Nociceptive Responses of the Orbicularis Oculi Reflex in Alzheimer's Disease: State of the Evidence and Meta-analysis
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The Three Nociceptive Responses of the Orbicularis Oculi Reflex in Alzheimer's Disease: State of the Evidence and Meta-analysis

机译：阿尔茨海默氏病orbicularis oculi反射的三个伤害反应：证据和荟萃分析的状态

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摘要

There is an emerging belief that electrically elicited blink reflexes (BR) may distinguish Alzheimer's disease (AD) from other disorders characterized by memory dysfunction. To qualitatively and quantitatively distinguish the effects that electrical stimulation has over the blink reflex (eBR) recorded from patients with AD and healthy controls (HCs), we did a systematic review of the literature, and conducted a meta-analysis. Following our selected criteria, 94 AD patients and 97 HCs were identified from articles published in English between 1950 and 2017. Although the 3 responses (R1, R2 and R3) of the eBR were studied in a number of patients, only the R2 response was quantified in all studies. Thresholds and stimulation intensities parameters were found to be used in a miscellaneous form, and the majority of times, such parameters deviated from validated guidelines. The stimulation frequencies used to elicit the BR responses ranged between 0.14 and 0.2 Hz. These frequencies favored HCs compared with AD patients (odds ratio = 1.08; 95% CI = 0.30-1.85), I-2 = 0% [P = .99]; Q = 271.89 [df = 7, P < .000]). Egger's regression test suggested publication bias (intercept = 32.38; 95% CI = -8.98 to -3.2; P = .001). Our results unveiled key shortcomings in the data reported; such shortcomings need to be corrected in future AD research looking for obtaining more reliable and reproducible eBR studies; otherwise, interventions may be misleading.
机译：有一种新兴信念，即电引出的眨眼反射（BR）可以将阿尔茨海默病（AD）与记忆功能障碍特征的其他疾病区分开来。为了定性和定量地区分电刺激对来自AD和健康对照（HCS）患者记录的眨眼反射（EBR）的影响，我们对文献进行了系统的审查，并进行了荟萃分析。遵循我们所选标准，94名AD患者和97个HCS从1950年至2017年间英语发表的文章中确定了。虽然在一些患者中研究了EBR的3个反应（R1，R2和R3），但只有R2反应是在所有研究中量化。发现阈值和刺激强度参数以杂项形式使用和大多数时间，这些参数偏离有验证的指南。用于引出BR响应的刺激频率范围为0.14和0.2Hz。这些频率赞成HCS与AD患者（差价率= 1.08; 95％CI = 0.30-1.85），I-2 = 0％[P = .99]; q = 271.89 [df = 7，p <.000]）。 Egger的回归测试建议出版物偏压（拦截= 32.38; 95％CI = -8.98至-3.2; p = .001）。我们的结果揭示了报告的数据中的关键缺点;需要在未来的广告研究中纠正这种缺点，寻求获得更可靠和可重复的EBR研究;否则，干预可能是误导性的。

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