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首页> 外文期刊>Comparative biochemistry and physiology, Part D. Genomics & proteomics >The distinct transcriptomes of fast-twitch and slow-twitch muscles in Mongolian horses
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The distinct transcriptomes of fast-twitch and slow-twitch muscles in Mongolian horses

机译：在蒙古马的快速抽搐和缓慢抽搐肌肉的不同转录om

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摘要

Skeletal muscle is the largest organ system in the mammalian body and plays a key role in locomotion of horses. Fast and slow muscle fibers have different abilities and functions to adapt to exercises. To investigate the RNA and miRNA expression profiles in the muscles with different muscle fiber compositions on Mongolian horses. We examined the muscle fiber type population and produced deep RNA sequencing for different parts of skeletal muscles. And chose two of them with the highest difference in fast and slow muscle fiber population (splenius and gluteus medius) for comparing the gene expression profile of slow and fast muscle fiber types. We identified a total of 275 differentially expressed genes (DEGs), and 11 differentially expressed miRNAs (DEmiRs). In addition, target gene prediction and alternative splicing analysis were also performed. Significant correlations were found between the differentially expressed gene, miRNAs, and alternative splicing events. The result indicated that differentially expressed muscle-specific genes and target genes of miRNAs might co-regulating the performance of slow and fast muscle fiber types in Mongolian horses.
机译：骨骼肌是哺乳动物体内最大的器官系统，在马的运动中发挥着关键作用。快速和缓慢的肌肉纤维具有不同的能力和功能来适应练习。研究蒙古马的不同肌纤维组合物的肌肉中的RNA和miRNA表达谱。我们检查了肌肉纤维型群体，并为骨骼肌的不同部位产生了深的RNA测序。并在快速和缓慢肌肉纤维群（Splenius和Gluteus Medius）中选择其中的最高差异，用于比较缓慢和快速肌纤维类型的基因表达谱。我们鉴定了总共275个差异表达基因（DEG）和11个差异表达的miRNA（Demirs）。此外，还进行了靶基因预测和替代剪接分析。在差异表达的基因，miRNA和替代剪接事件之间发现了显着的相关性。结果表明，差异表达的肌肉特异性基因和miRNA的靶基因可能共同调节蒙古马慢速肌纤维类型的性能。

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