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A Review of Pain Assessment Methods in Laboratory Rodents

机译：实验室啮齿动物疼痛评估方法综述

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Ensuring that laboratory rodent pain is well managed underpins the ethical acceptability of working with these animals in research. Appropriate treatment of pain in laboratory rodents requires accurate assessments of the presence or absence of pain to the extent possible. This can be challenging some situations because laboratory rodents are prey species that may show subtle signs of pain. Although a number of standard algesiometry assays have been used to assess evoked pain responses in rodents for many decades, these methods likely represent an oversimplification of pain assessment and many require animal handling during testing, which can result in stress-induced analgesia. More recent pain assessment methods, such as the use of ethograms, facial grimace scoring, burrowing, and nest-building, focus on evaluating changes in spontaneous behaviors or activities of rodents in their home environments. Many of these assessment methods are time-consuming to conduct. While many of these newer tests show promise for providing a more accurate assessment of pain, most require more study to determine their reliability and sensitivity across a broad range of experimental conditions, as well as between species and strains of animals. Regular observation of laboratory rodents before and after painful procedures with consistent use of 2 or more assessment methods is likely to improve pain detection and lead to improved treatment and care-a primary goal for improving overall animal welfare.
机译：确保实验室啮齿动物疼痛得到很好的管理，基础是在研究中使用这些动物的道德可接受性。在实验室啮齿动物的适当治疗疼痛需要准确评估存在或不存在疼痛的程度。这可能是挑战某些情况，因为实验室啮齿动物是可能表现出痛苦的微妙迹象的猎物。尽管已经使用了许多标准的Algesiometry测定来评估啮齿动物中的诱发疼痛反应数十年，但这些方法可能代表疼痛评估的过度简化，并且许多需要在测试期间进行动物处理，这可能导致应激诱导的镇痛。最近的疼痛评估方法，例如使用征区，面部​​鬼脸评分，挖洞和筑巢，专注于评估其家庭环境中自发行为或啮齿动物活动的变化。许多这些评估方法是耗时的行为。虽然许多这些新的测试显示了提供更准确的疼痛评估的承诺，但大多数需要更多的研究来确定他们在广泛的实验条件下的可靠性和敏感性，以及动物的物种和动物菌株之间。经常观察实验室啮齿动物在疼痛手术前后使用2或更多评估方法的痛苦手术，可能改善疼痛检测并导致改善治疗和关怀 - 改善整体动物福利的主要目标。

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