• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative Medicine >Effective Prophylactic Therapy for Exposure to Monkey B Virus (Macacine alphaherpesvirus 1)
【24h】

Effective Prophylactic Therapy for Exposure to Monkey B Virus (Macacine alphaherpesvirus 1)

机译：有效的预防性治疗猴B病毒（Macacine Alphaherpesvirus 1）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Zoonotic monkey B virus (Macacine alphaherpesvirus 1; BV) infections are extremely serious and usually fatal. Drugs currently used for treatment were developed for the treatment of herpes simplex virus but are less effective against By. Effective suppression of viral replication in the skin could prevent the virus from invading the nervous system. To test this hypothesis, the efficacy of topical administration of several drugs against lethal BV infection was evaluated in female BALB/c mice that were infected by scarification. Drugs were then applied to the site of inoculation. As 3% preparations, most drugs were only minimally effective or ineffective. In contrast, ganciclovir and cidofovir were very effective. The ED50 for cidofovir was 0.007%, compared with 1.1% for ganciclovir. At 0.5%, cidofovir protected against both death and neurologic signs, whereas 5% ganciclovir only protected against death but not neurologic involvement. All genotypes of BV were equally susceptible to cidofovir and ganciclovir. For maximal effectiveness, treatment with both cidofovir and ganciclovir had to be initiated within 8 h of infection. Cidofovir was completely protective when administered only on the day of infection, whereas a minimum of 5 d of treatment was required for maximal ganciclovir efficacy. These studies showed that topical cidofovir treatment started soon after BV exposure was very effective in preventing BV from invading the nervous system, whereas ganciclovir treatment was only partially effective. In addition, cidofovir was protective against a ganciclovir-resistant BV mutant, whereas ganciclovir was not. These studies showed that topical cidofovir treatment started soon after BV exposure is more effective than ganciclovir in preventing BV from invading the CNS.
机译：动物园猴B病毒（Macacine Alphaherpesvirus 1; BV）感染极为严重，通常是致命的。目前用于治疗的药物是为了治疗单纯疱疹病毒而是效果较小。有效地抑制皮肤中的病毒复制可以防止病毒入侵神经系统。为了测试这一假设，在感染的雌性Balb / C小鼠中评估了几种药物对致死的BV感染的局部给药的疗效。然后将药物施用于接种位点。作为3％的制剂，大多数药物只能有效或无效。相比之下，Ganciclovir和Cidofovir非常有效。 Cidofovir的ED50为0.007％，而Ganciclovir的1.1％。番木夫血症均为0.5％，保护针对死亡和神经系统症状，而5％的甘昔韦尔只能免受死亡而不是神经系统参与。 BV的所有基因型同等易于Cidofovir和Ganciclovir。对于最大效果，必须在感染的8小时内启动含Cidofovir和Ganciclovir的治疗。当仅在感染当天施用时，Cidofovir完全是保护性的，而最大的Ganciclovir疗效需要至少5 d治疗。这些研究表明，在BV暴露后立即开始局部CidoFovir治疗在预防BV入侵神经系统时，较高的治疗仅部分有效。此外，Cidofovir对抗性抗性的BV突变体进行了保护，而Ganciclovir不是。这些研究表明，在BV暴露之后，在预防BV侵入CNS时，在BV暴露之后，在BV暴露中更有效地开始局部Cidofovir治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号