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Beyond the pill: new medication delivery options for ADHD

机译：除了丸之外：ADHD的新药物交付选择

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摘要

Successful treatment of pediatric disorders has necessitated the development of alternative medication formulations, as children may prefer alternative dosage forms to tablets or capsules. This is especially true for attention-deficit/hyperactivity disorder (ADHD), which is one of the most common chronic pediatric conditions and often involves children with a variety of overlapping physical, psychological, or neurodevelopmental disorders. A special challenge for developing alternative dosage forms for ADHD treatment is the incorporation of a once-daily long-acting formulation. Traditional ADHD medication formulations have been limited, and issues surrounding prescribed dosing regimens—including poor medication adherence, difficulty swallowing, and the lack of dosing titration options—persist in ADHD treatment. In other disease areas, the development of alternative formulations has provided options for patients who have issues with consuming solid dosage forms, particularly children and individuals with developmental disorders. In the light of these new developments, several alternative formulations for ADHD medications are under development or have recently become available. This article reviews the various strategies for developing alternative dosage forms in other disease areas and discusses the application of these strategies in ADHD treatment. Alternative dosage forms may increase medication adherence, compliance, and patient preference and, therefore, improve the overall treatment for ADHD.
机译：儿科疾病的成功治疗需要替代药物制剂的发展，因为儿童可以偏爱替代剂型给片剂或胶囊。对于注意力缺陷/多动障碍（ADHD）尤其如此，这是最常见的慢性小儿病症之一，并且往往涉及具有各种重叠的物理，心理或神经发育障碍的儿童。用于开发ADHD治疗的替代剂型的特别挑战是掺入曾经每日的长效制剂。传统的ADHD药物配方受到限制，并围绕规定的给药方案的问题 - 包括糟糕的药物粘附，吞咽困难，缺乏计量滴定选项 - 在ADHD治疗中持续存在。在其他疾病领域，替代配方的发展为患者提供了患者的选择，该患者患有消耗的持续剂型，特别是儿童和具有发育障碍的个体的问题。鉴于这些新的发展，若干替代的ADHD药物制剂正在开发或最近可用。本文审查了在其他疾病区域开发替代剂型的各种策略，并探讨了这些策略在ADHD治疗中的应用。替代剂型可以增加药物依从性，依从性和患者偏好，因此改善ADHD的整体处理。

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