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Emerging treatments for the behavioral and psychological symptoms of dementia

机译：痴呆症行为和心理症状的新兴治疗

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Dementia is referred to a loss of memory and decline in other mental abilities at levels critical enough to hinder performance of daily activities. It can be of several types, depending on the underlying pathophysiology. The behavioral and psychological symptoms of dementia (BPSD) are various, but the most clinically significant are depression, apathy, and anxiety. Other BPSD include agitation, aberrant motor behavior, elation, hallucinations, and alterations in sleep and appetite. About 90% of sufferers of dementia are affected by BPSD during the course of the illness. These symptoms occur in demented patients irrespective of the dementia subtype. However, there has not been significant development in the areas of disease-modifying pharmacotherapeutics for dementia. Therefore, tackling BPSD has emerged as a research avenue in the recent past. Existing antidepressants, antipsychotics, and cholinergic agents have been extensively used in the treatment of BPSD, independently and in different combinations. However, these agents have not successful in completely alleviating such symptoms. Research in this field is going on globally, but it is still limited by various factors. There is a strong need to develop new entities and test them clinically. This review focuses on emerging treatments for the management of clinically significant BPSD.
机译：痴呆症被称为记忆丧失和其他心理能力的下降，其水平足以满足日常活动的绩效。这可能是几种类型，具体取决于潜在的病理生理学。痴呆症（BPSD）的行为和心理症状是各种各样的，但最临床显着的是抑郁症，冷漠和​​焦虑。其他BPSD包括搅拌，异常电机行为，孕育，幻觉和睡眠和食欲的改变。在疾病过程中，大约90％的痴呆患者受到BPSD的影响。这些症状发生在痴呆患者中，无论痴呆亚型如何。然而，在痴呆症的疾病改性药物治疗方法中没有显着发展。因此，Tackling BPSD已成为最近过去的研究大道。现有的抗抑郁药，抗精神病药和胆碱能药物已被广泛地用于治疗BPSD，独立地和不同组合。然而，这些药剂在完全缓解这些症状方面并没有成功。该领域的研究正在全球范围内进行，但它仍然受到各种因素的限制。强烈需要开发新实体并临床测试它们。该审查重点介绍了新出现的临床显着的BPSD治疗。

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