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首页> 外文期刊>Contact dermatitis >CD44 expression in human skin: High expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls
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CD44 expression in human skin: High expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls

机译：CD44人体皮肤中的表达：与健康对照相比，刺激性和过敏性接触皮炎的高表达和牛皮癣病变中的中等表达

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Abstract Background Previous research using animal models demonstrated that CD44 expression may contribute to directing inflammatory cells into skin lesions during inflammation development in allergic contact dermatitis (ACD). Objectives To examine CD44 expression in patients with ACD and irritant contact dermatitis (ICD), and to compare it to patients with psoriatic lesions and healthy controls’ (HCs) skin. Methods This study included 200 patients comprising four groups of 50 each: ACD, ICD, psoriasis vulgaris, and HCs. CD44 expression was determined by immunohistochemical analysis using an optical microscope, and the results were visualized semiquantitatively by determining the percentage of immunoreactive cells in the epidermis, dermis, and on lymphocytes. Results The highest CD44 expression was found in ICD, followed by ACD, psoriasis vulgaris, and lastly, the HCs ( P ??.001). Epidermal CD44 expression was significantly higher in contact dermatoses (especially in ICD) compared with psoriasis and healthy skin ( P ??.001). Similarly, CD44 expression in the dermis and on lymphocytes was strongest in ICD, although less pronounced than in the epidermis. Conclusions Because significantly elevated CD44 expression in ICD might be related to its function in maintaining and preserving the skin barrier in affected patients, further research on disease pathogenesis and new treatment options is needed.
机译：摘要背景以前使用动物模型的研究证明CD44表达可能导致在过敏性接触皮炎（ACD）的炎症发育过程中引导炎症细胞进入皮肤病变。目的在患有ACD和刺激性皮炎（ICD）患者中检查CD44表达，并将其与银屑病病变和健康对照（HCS）皮肤的患者进行比较。方法本研究包括200名患者，包括四组5个组：ACD，ICD，牛皮癣和HCS。通过使用光学显微镜通过免疫组织化学分析测定CD44表达，并通过测定表皮，真皮和淋巴细胞上的免疫反应细胞的百分比来半定量结果。结果在ICD中发现了最高的CD44表达，其次是ACD，牛皮癣，最后，HCS（p？＆ 001）。与牛皮癣和健康皮肤相比类似地，在ICD中，真皮和淋巴细胞中的CD44表达最强，但比表皮少明显。结论由于ICD中的CD44表达明显升高可能与其在受影响患者中的皮肤屏障保持和保留皮肤屏障有关的情况下，需要进一步研究疾病发病机制和新的治疗选择。

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