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首页> 外文期刊>Acta microbiologica et immunologica Hungarica: A quarterly of the Hungarian Academy of Sciences >Characterisation of the first VIM metallo-beta-lactamase-producing Pseudomonas aeruginosa clinical isolate in Serbia.
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Characterisation of the first VIM metallo-beta-lactamase-producing Pseudomonas aeruginosa clinical isolate in Serbia.

机译：塞尔维亚第一个产生VIM金属-β-内酰胺酶的铜绿假单胞菌临床分离株的表征。

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From the Central-East European region the first VIM metallo-beta-lactamase (MBL) producing Pseudomonas aeruginosa strains were published from Croatia, Poland and Hungary. The aim of this study was to assess the contribution of MBL-production to carbapenem-resistance among P. aeruginosa clinical isolates in the Military Medical Academy (MMA) in Belgrade, Serbia between August 2004 and September 2007. Only one P. aeruginosa isolate with strain number 722 proved MBL-positive that harboured a novel class 1 integron with a bla(VIM-2)-like cassette in the first position, followed by orfD, a putative gene with unknown function. Our data indicate that MBL-producing strains occur at a prevalence of less than 1% among imipenem-nonsusceptible P. aeruginosa clinical isolates in this Belgrade hospital. The newly identified VIM MBL-producing P. aeruginosa strain 722 could be assigned to serotype O11, and it was panresistant to all antimicrobials tested. The isolate displayed sequence type ST235 by multilocus sequence typing which is the founder sequence type of the previously identified international clonal complex CC11 that already contains bla(VIM)-positive isolates from Italy, Greece, Sweden, Hungary and Poland. In conclusion, this is the first report of VIM MBL-producing P. aeruginosa from Serbia and also of the occurrence of such isolates belonging to the international clonal complex CC11 in this country.
机译：在中东欧地区，克罗地亚，波兰和匈牙利发布了第一批产生VIM金属β-内酰胺酶（MBL）的铜绿假单胞菌菌株。这项研究的目的是评估2004年8月至2007年9月在塞尔维亚贝尔格莱德的军事医学学院（MMA）的铜绿假单胞菌临床分离株中MBL产生对抗碳青霉烯的贡献。 722号菌株证明MBL阳性，其第一末端带有bla（VIM-2）样盒带的新型1类整合子，其次是orfD，其功能未知。我们的数据表明，在这家贝尔格莱德医院，亚胺培南不敏感的铜绿假单胞菌临床分离株中，MBL产生菌株的发生率不到1％。可以将新鉴定出的产生VIM MBL的铜绿假单胞菌菌株722归类为O11血清型，它对所有测试的抗生素均具有全能性。分离株通过多基因座序列分型显示了ST235序列类型，这是先前鉴定的国际克隆复合体CC11的创建者序列类型，该序列已经包含来自意大利，希腊，瑞典，匈牙利和波兰的bla（VIM）阳性分离株。总之，这是来自塞尔维亚的VIM MBL产铜绿假单胞菌的首次报道，也是该国属于国际克隆复合体CC11的这种分离株的报道。

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