• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cornea >Relationship Between Ocular Surface Epithelial Damage, Tear Abnormalities, and Blink in Patients With Dry Eye
【24h】

Relationship Between Ocular Surface Epithelial Damage, Tear Abnormalities, and Blink in Patients With Dry Eye

机译：干眼症患者眼表面上皮损伤，撕裂异常与眨眼之间的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: Considering that tears play the role of a lubricant, it is speculated that in the pathophysiology of dry eye, increased friction during blinking results in corneal and conjunctival damage, which may subsequently affect the blink. The purpose of this study was to investigate the relationship between ocular surface epithelial damage, tear abnormalities, and blinks in patients with dry eye. Methods: This study involved 45 eyes of 45 female patients with dry eye (mean age: 57.6 years). In all eyes, tear meniscus radius (mm), spread grade of the tear film lipid layer (SG: 1-5: 1 being the best), fluorescein breakup time (FBUT, seconds), corneal and bulbar conjunctival epithelial damage (CED: 15 points maximum and CONJUNCTIVAL EPITHELIAL DAMAGE (CjED): 6 points maximum, respectively), and Schirmer I test (ST1, mm) were evaluated. Blink rate (BR, blinks per minute), palpebral aperture height (mm), upper-eyelid opening-phase amplitude/upper-eyelid closing-phase amplitude (mm), upper-eyelid opening-phase duration/upper-eyelid closing-phase duration (ms), and upper-eyelid opening-phase maximum velocity/upper-eyelid closing-phase maximum velocity (mm/s) were measured using a custom-made high-speed blink analyzer. Finally, the factors that determine CED and CjED were investigated by multiple regression analysis, in which the parameters were chosen using the stepwise procedure. Results: CED and CjED were found to be described as 2.687 + (1.816 x SG) - (0.937 x FBUT) (R-2 = 0.656, P < 0.0001) and 0.684 + (0.801 x SG) - (0.526 x FBUT) - (0.041 x ST1) + (0.010 x upper-eyelid closing-phase maximum velocity) (R-2 = 0.714, P < 0.0001), respectively. Conclusions: Although CED was significantly related to only tear abnormalities, CjED was significantly related to tear abnormalities and blinking.
机译：目的：考虑到泪水发挥润滑剂的作用，据推测，在干眼症的病理生理学中，在闪烁期间增加了角膜和结膜损伤期间的摩擦，这可能随后影响眨眼。本研究的目的是研究眼部表面上皮损伤，撕裂异常的关系，干燥眼睛患者眨眼。方法：本研究涉及45只患有干眼症患者的45只眼（平均年龄：57.6岁）。在所有的眼睛里，泪圈半径（mm），泪水脂肪层的涂抹等级（sg：1-5：1是最好的），荧光素分发时间（fbut，秒），角膜和鳞杆菌结膜上皮损伤（ced： 15分最大和结膜上皮损伤（CJED）：最大6分），并评估Schirmer I测试（ST1，mm）。闪烁速率（BR，眨眼每分钟），睑观高度（mm），上眼睑开口相位幅度/上眼睑闭合相位幅度（mm），上眼睑开口相位持续时间/上眼睑闭合相使用定制的高速闪烁分析仪测量持续时间（MS）和上眼睑开口相位最大速度/上眼睑闭合相位最大速度（MM / s）。最后，通过多元回归分析研究了确定CED和CJED的因素，其中使用逐步程序选择参数。结果：CED和CJED被发现将描述为2.687 +（1.816 x SG） - （0.937 x FBUT）（R-2 = 0.656，P <0.0001）和0.684 +（0.801 x SG） - （0.526 x FBUT） - （0.041 x st1）+（0.010 x上眼睑闭合相位最大速度）（R-2 = 0.714，p <0.0001）。结论：虽然CED与仅撕裂异常有显着相关，但CJED与撕裂异常和闪烁显着相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号