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首页> 外文期刊>Cornea >Corneal Endothelial Cell Density and Morphology After Phacoemulsification in Patients With Primary Open-Angle Glaucoma and Cataracts: 2-Year Results of a Randomized Multicenter Trial
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Corneal Endothelial Cell Density and Morphology After Phacoemulsification in Patients With Primary Open-Angle Glaucoma and Cataracts: 2-Year Results of a Randomized Multicenter Trial

机译：初级开角青光眼和白内障患者沉重乳化后角膜内皮细胞密度和形态：随机多中心试验的2年结果

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Purpose: To evaluate corneal endothelial cell density (ECD) and morphology 2 years after phacoemulsification in subjects from the COMPASS trial (, NCT01085357) who had mild-to-moderate primary open-angle glaucoma and visually significant cataracts. Methods: The central corneal endothelium was evaluated by serial specular microscopy at 0 to 24 months. ECD, coefficient of variation, and percentage of hexagonal cells were evaluated by a central image analysis reading center and central corneal thickness (CCT) was evaluated by ultrasound pachymetry. Results: Of 131 subjects who underwent routine phacoemulsification, analyzable endothelial images at 24 months were available for 126 subjects (96.2%). Mean +/- SD central ECD at baseline was 2453 +/- 359 cells/mm(2), decreasing by 10% +/- 14% to 2195 +/- 517 cells/mm(2) at 3 months (P 30% ECL at 12 and 24 months, respectively. Neither coefficient of variation nor percentage of hexagonal cells changed significantly from baseline at any time point. Mean CCT was similar at baseline (550 +/- 35 mu m) and at 12 months (551 +/- 37 mu m) and 24 months (555 +/- 35 mu m). Age was significantly associated with ECL after cataract surgery (P = 0.02), but baseline intraocular pressure, number of glaucoma medications, and CCT were not. Similar results were observed in patients who underwent CyPass micro-stent implantation accompanying phacoemulsification. Conclusions: Phacoemulsification in eyes with mild-to-moderate primary open-angle glaucoma results in early ECL, with ECD stabilizing after 3 months and no effect on other endothelial stress markers up to 2 years postoperatively.
机译：目的：评估来自征服初级初级开角青光眼和视觉显着性白内障的Compass试验（NCT01085357）中沉重乳化后2年的角膜内皮细胞密度（ECD）和形态学。方法：中央角膜内皮通过连续镜面显微镜评估0至24个月。通过超声波触发评估ECD，通过中央图像分析读取中心评估六方细胞的变异系数和六方细胞的百分比。结果：131名经过常规沉乳化的受试者，可分析24个月的内皮图像可用于126个受试者（96.2％）。基线的平均+/- SD中央ECD为2453 +/- 359细胞/ mm（2），在3个月内减少10％+/- 14％至2195 +/- 517细胞/ mm（2）（p 30％） ECL分别在12和24个月。既不是在任何时间点的基线变异系数也没有六边形细胞的百分比变化。平均CCT在基线（550 +/-35μm）和12个月（551 + / - 37 mu m）和24个月（555 +/- 35 mu m）。白内障手术后年龄与ECL显着相关（p = 0.02），但基线眼内压，青光眼的药物数量和CCT没有。类似的结果在伴随沉乳化学乳化的患者中进行了患者的患者观察到。结论：具有轻度至中等的原发性开口角度青光眼的眼睛乳化，导致早期ECL，3个月后ECD稳定，对其他内皮应激标记没有影响术后2年。

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