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首页> 外文期刊>Current opinion in clinical nutrition and metabolic care >Role of hepatic desaturases in obesity-related metabolic disorders.
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Role of hepatic desaturases in obesity-related metabolic disorders.

机译：肝脏去饱和酶在肥胖相关的代谢障碍中的作用。

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PURPOSE OF REVIEW: This review aims to address the latest research on hepatic desaturases and metabolic disorders, with focus on stearoyl-CoA desaturase-1 (SCD-1) indices in observational studies. RECENT FINDINGS: In animal studies, SCD-1 inhibition protects against features of the metabolic syndrome and is associated with improved hepatic insulin resistance and decreased steatosis. In human observational studies, higher estimated hepatic SCD-1 and Delta6-desaturase activities predict the metabolic syndrome, insulin resistance and mortality whereas Delta5-desaturase index is often inversely related. However, because the desaturase activities in the liver and adipose tissue may not be regulated in parallel, it is important to define used lipid fractions when comparing studies. It is also important to take the background diets of the populations into account when comparing studies. Moreover, there may be a divergence in desaturase regulation depending on glycaemic control among individuals. SUMMARY: Increased SCD-1 indices reflecting liver desaturase activity have been associated with insulin resistance, fatty liver, the metabolic syndrome and mortality. However, it remains to be determined if high hepatic SCD-1 activity plays a direct role in the development of metabolic disorders or rather is a marker for an unfavourable diet or hepatic insulin resistance.
机译：审查目的：本报告旨在解决对肝脏去饱和酶和代谢紊乱的最新研究，重点是Stearoyl-CoA去饱和酶-1（SCD-1）在观察研究中的指标。最近的发现：在动物研究中，SCD-1抑制保护代谢综合征的特征，与改善的肝胰岛素抵抗和降低的脂肪变性有关。在人类观察性研究中，估计肝脏SCD-1和Delta6-去饱和酶活性预测代谢综合征，胰岛素抵抗和死亡率，而Delta5-去饱和酶指数往往与关系成反比。然而，因为肝脏和脂肪组织中的去饱和酶活性可能不平行调节，所以在比较研究时定义使用的脂质级分是重要的。在比较研究时考虑群体的背景饮食也很重要。此外，取决于个体血糖对照的去饱和酶调节中可能存在分歧。发明内容：增加反映肝脏去饱和酶活性的SCD-1索引与胰岛素抵抗，脂肪肝，代谢综合征和死亡率有关。然而，如果高肝脏SCD-1活性在代谢紊乱的发展中发挥直接作用，或者是用于不利饮食或肝胰岛素抵抗的标志物，仍有待确定。

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