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Pathogen inactivation: Coming of age

机译：病原体失活：年龄的到来

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PURPOSE OF REVIEW: In the past 20 years, several pathogen inactivation technologies have been developed to be applied to blood components. This review is intended to summarize the data currently available about the technologies and the clinical use of products inactivated by those techniques. RECENT FINDINGS: Technologies for inactivating pathogens in plasma and platelets are available, and are increasingly used in many countries. Cumulative experience over the last decade in routine use supports the concept of the safety and efficacy of the blood components treated with pathogen inactivation technologies. SUMMARY: In recent years, an increase in the use of pathogen inactivation technologies for plasma and platelets has been observed. Their routine use in addition to experience generated in controlled clinical trials confirms that the treated blood components meet the required efficacy and safety criteria. Differences in epidemiology between countries, infectious risk perception, concerns about potential adverse effects associated with its use, and economic considerations of national blood systems might explain the differences observed in its implementation.
机译：审查目的：在过去20年中，已经开发了几种病原体灭活技术以应用于血液成分。该审查旨在总结当前关于技术的数据以及这些技术灭活的产品的临床应用。最近的发现：可提供用于在血浆和血小板中灭活病原体的技术，并且越来越多地用于许多国家。在过去十年中，常规用途的累积经验支持使用病原体灭活技术治疗的血液成分的安全性和功效的概念。发明内容：近年来，已经观察到使用血浆和血小板使用病原体失活技术的增加。他们的常规使用除了受控临床试验中生成的经验还证实了处理过的血液组分符合所需的疗效和安全标准。国家之间流行病学的差异，传染病风险感知，关于与其使用相关的潜在不利影响的担忧，以及国家血液系统的经济考虑可能会解释其实施中所观察到的差异。

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