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Visualization of Trigeminal Ganglion Neuronal Activities in Mice

机译：小鼠三叉神经节神经元活性的可视化

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摘要

Visualization of dynamic cellular activity has greatly expanded our understanding of brain function. Recently, there has been an increasing number of studies imaging rodent brain activity in real time. However, traditional in vivo calcium imaging technology has been limited to superficial brain structures. Because the trigeminal ganglion (TG) is located deep within the cranial cavity of mice, few studies have been able to access to it. To circumvent this limitation, overlying brain tissue must be removed to expose the TG so that optical recording can access deep brain neural ensembles. This unit describes a procedure for conducting non-survival surgery to visualize the TG in live mice. Obtaining large ensembles of direct, real-time readouts of sensory neuron signaling, providing temporal and spatial information across the TG, will help to define the cellular basis of orofacial somatic sensing and pain perception.
机译：动态蜂窝活动的可视化极大地扩展了我们对大脑功能的理解。 最近，越来越多的研究成像啮齿动物脑活动实时。 然而，传统的体内钙成像技术仅限于浅表脑结构。 因为三叉神经节（TG）位于小鼠的颅腔内深处，所以很少有研究能够进入它。 为了避免这种限制，必须去除覆盖的脑组织以暴露TG，使得光学记录可以进入深脑神经系列。 本机描述了进行非生存手术的过程以在活小鼠中可视化TG。 获得大型直接，实时读数的大型集合，在TG上提供时间和空间信息，将有助于定义orofacial躯体传感和疼痛感知的细胞基础。

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