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Weight-adapted ultra-low-dose pancreatic perfusion CT: radiation dose, image quality, and perfusion parameters

机译:重量适应超低剂量胰灌注CT:辐射剂量,图像质量和灌注参数

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Purpose We evaluate the reliability and feasibility of weight-adapted ultra-low-dose pancreatic perfusion CT. Methods A total of 100 (47 men, 53 women) patients were enrolled prospectively and were assigned to five groups (A, B, C, D, and E) with different combination of tube voltage and tube current according to their body weight. Radiation dose parameters including volume CT dose index (CTDI) and dose-length product (DLP) were recorded. Image quality was evaluated both subjectively and objectively (noise, signal-to-noise ratio, contrast-to-noise ratio). Perfusion parameters including blood flow (BF), blood volume (BV), and permeability (PMB) were measured. The dose, image quality measurements, and perfusion parameters were compared between the five groups using one-way analysis of variance (ANOVA). Results Radiation dose reached 8.7 mSv in patients under 50 kg and was 18.9 mSv in patients above 80 kg. The mean subjective image quality score was above 4.45 on a 5-point scale with good agreement between two radiologists. Groups A-D had equivalent performance on objective image quality (P>0.05), while Group E performed even better (P<0.05). No significant differences emerged in comparison with perfusion parameters (BF, BV, PMB) of normal pancreas parenchyma between the five groups. Conclusion Weight-adapted ultra-low-dose pancreatic perfusion CT can effectively reduce radiation dose without prejudice to image quality, and the perfusion parameters of normal parenchyma are accurate and reliable.
机译:目的我们评估体重适应的可靠性和可行性超低剂量胰腺CT灌注。方法将100(47名男,53名女性)患者前瞻性纳入并根据他们的体重分为5组(A,B,C,d,和E)与管电压和管电流的不同组合。辐射剂量的参数,包括体积CT剂量指数(CTDI)和剂量长度乘积(DLP)的记录。图像质量进行评价两者主客观(噪声,信噪比,对比度与噪声之比)。测定灌注参数,包括血流量(BF),血液体积(BV)和渗透性(PMB)。剂量,图像质量测量,和灌注参数是使用方差分析(ANOVA)的单向分析五个组之间进行比较。结果辐射剂量达到8.7毫患者在50公斤的患者以上80公斤为18.9毫。平均主观图像质量得分高于4.45在5分制有两个放射科医师之间良好的一致性。组A-d对客观的图像质量(P> 0.05)相同的性能,而E组进行甚至更好(P <0.05)。无显著差异与五组之间的正常胰腺实质的灌注参数(BF,BV,PMB)相比出现了。结论重适于超低剂量胰灌注CT可以有效地减少辐射剂量不妨碍图像质量,和正常实质的灌注参数是准确和可靠。

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