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首页> 外文期刊>Academic radiology >MR Elastography in Renal Transplant Patients and Correlation with Renal Allograft Biopsy. A Feasibility Study
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MR Elastography in Renal Transplant Patients and Correlation with Renal Allograft Biopsy. A Feasibility Study

机译：肾移植患者先生的弹性术和与肾同种异体移植活检的相关性。 可行性研究

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摘要

Rationale and Objectives: Magnetic resonance elastography (MRE) images the propagation of mechanical shear waves in tissue and uses that information to generate quantitative measures of tissue stiffness. Hepatic MRE has been successfully performed in thousands of patients, with good correlation between histologic grade of fibrosis and tissue stiffness. There has been no prior investigation of the utility of MRE for the assessment of kidney transplants. The aims of this study were to prospectively evaluate the feasibility of MRE in a small group of kidney transplant recipients and to correlate the measured magnetic resonance elastographic stiffness values with biopsy-proven histopathologic fibrosis. Materials and Methods: MRE of renal transplants was performed in 11 patients returning for protocol allograft biopsies. Calculated tissue stiffness values were compared to histologic degree of fibrosis in nine of the 11 patients. Results: The mean stiffness of two patients with moderate interstitial fibrosis was higher than the mean of six patients with mild interstitial fibrosis, but not significantly so (90 Hz, P = .12; 120 Hz, P = .17; 150 Hz, P = .26). The mean stiffness of the two patients with moderate interstitial fibrosis was slightly greater than the mean of one patient with no significant interstitial fibrosis at 90 Hz (P = .78) and slightly less at 120 and 150 Hz (P = .88 and P = .76). The mean stiffness of the six patients with mild interstitial fibrosis did not differ significantly from that of the one patient with no interstitial fibrosis (90 Hz, P = .35; 120 Hz, P = .22; 150 Hz, P = .16). Conclusions: Preliminary results demonstrate feasibility and support known multifactorial influences on renal stiffness.
机译：理由和目标：磁共振弹性造影（MRE）图像在组织中的机械剪切波的传播并使用该信息产生组织刚度的定量测量。肝脏MRE已成功地在成千上万的患者中进行，纤维化和组织刚度的组织学等学与组织学等学之间的相关性良好。没有事先调查MRE用于评估肾移植的实用性。本研究的目的是对一小组肾移植受者进行前瞻性评估MRE的可行性，并将测量的磁共振弹性刚度值与活检证明的组织病理学纤维化相关联。材料和方法：在11例返回方案同种异体移植活检的11名患者中进行了肾移植物。将计算出的组织刚度值与11名患者的九个中九个纤维化的组织学程度进行比较。结果：两种中间质纤维化患者的平均刚度高于6例患有轻度间质纤维化的患者，但不明显（90 Hz，P = .12; 120 Hz，P = .17; 150 Hz，p = .26）。两种中间质纤维化患者的平均刚度略大于一个患者在90 Hz（p = .78）下没有显着间质纤维化的平均值，略低于120和150 Hz（p = .88和p = .76）。 6例轻度间质纤维化患者的平均刚度并没有显着差异，从没有间质纤维化（90 Hz，P = .35; 120Hz，P = .22; 150 Hz，P = .16） 。结论：初步结果表明可行性和支持已知的多因素对肾刚度的影响。

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  • 来源
    《Academic radiology》 |2012年第7期|共8页
  • 作者

    LeeC.U.; GlocknerJ.F.; GlaserK.J.; YinM.; ChenJ.; KawashimaA.; KimB.; KremersW.K.; EhmanR.L.; GloorJ.M.;

  • 作者单位

    Department of Radiology Mayo Clinic 200 First Street SW Rochester MN 55905 United States;

    Department of Radiology Mayo Clinic 200 First Street SW Rochester MN 55905 United States;

    Center for Advanced Imaging Research Mayo Clinic 200 First Street SW Rochester MN 55905 United;

    Center for Advanced Imaging Research Mayo Clinic 200 First Street SW Rochester MN 55905 United;

    Center for Advanced Imaging Research Mayo Clinic 200 First Street SW Rochester MN 55905 United;

    Department of Radiology Mayo Clinic 200 First Street SW Rochester MN 55905 United States;

    Department of Radiology Mayo Clinic 200 First Street SW Rochester MN 55905 United States;

    Department of Biostatistics Mayo Clinic 200 First Street SW Rochester MN 55905 United States;

    Department of Radiology Mayo Clinic 200 First Street SW Rochester MN 55905 United States;

    Department of Nephrology and Hypertension Mayo Clinic 200 First Street SW Rochester MN 55905;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Kidney transplant; Magnetic resonance elastography; Renal transplant;

    机译：肾移植;磁共振弹性成像;肾移植;

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