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首页> 外文期刊>Acta biomaterialia >The effect of complexation hydrogels on insulin transport in intestinal epithelial cell models.
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The effect of complexation hydrogels on insulin transport in intestinal epithelial cell models.

机译：络合水凝胶对肠上皮细胞模型中胰岛素输送的影响。

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摘要

A novel class of pH-sensitive complexation hydrogels composed of methacrylic acid and functionalized poly(ethylene glycol) (PEG) tethers, referred to as P(MAA-g-EG) WGA, was investigated as an oral protein delivery system. The PEG tethers were functionalized with wheatgerm agglutinin (WGA), a lectin that can bind to carbohydrates in the intestinal mucosa, to improve residence time of the carrier and absorption of the drug at the delivery site. The ability of P(MAA-g-EG) WGA to improve insulin absorption was observed in two different intestinal epithelial models. In Caco-2 cells P(MAA-g-EG) WGA improved insulin permeability 9-fold as compared with an insulin only solution, which was similar to the improvement by P(MAA-g-EG). P(MAA-g-EG) and P(MAA-g-EG) WGA were also evaluated in a mucus-secreting culture that contained Caco-2 and HT29-MTX cells. Insulin permeability was increased 5-fold in the presence of P(MAA-g-EG) and P(MAA-g-EG) WGA. Overall, it is clear that P(MAA-g-EG) WGA enhances insulin absorption and holds great promise as an oral insulin delivery system.
机译：研究了由甲基丙烯酸和官能化聚（乙二醇）（PEG）的新型pH敏感络合水凝胶，称为P（MAA-G-EG）WGA，作为口服蛋白质输送系统。 PEG Thethers用WheatgerM凝集素（WGA）官能化，凝集素可以在肠粘膜中与碳水化合物结合，以改善载体的停留时间和药物在递送部位的吸收。在两种不同的肠上皮模型中观察到P（MAA-G-EG）WGA改善胰岛素吸收的能力。在CaCO-2细胞P（MAA-G-EG）中，与胰岛素的溶液相比，WGA改善了胰岛素渗透率9折叠，其与P（MaA-G-例如MaA-G-Em）的改善类似。在含有CaCO-2和HT29-MTX细胞的粘液分泌培养物中也评估P（MAA-G-EX）和P（MAA-G-EG）WGA。在P（MAA-G-EG）和P（MAA-G-EG）WGA存在下，胰岛素渗透率增加了5倍。总体而言，显然P（Maa-G-EG）WGA增强了胰岛素吸收，并具有作为口腔胰岛素递送系统的巨大希望。

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