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首页> 外文期刊>Acta biomaterialia >Scaffolds for 3D in vitro culture of neural lineage cells
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Scaffolds for 3D in vitro culture of neural lineage cells

机译：用于3D体外培养的神经谱系细胞的脚手架

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摘要

Understanding how neurodegenerative disorders develop is not only a key challenge for researchers but also for the wider society, given the rapidly aging populations in developed countries. Advances in this field require new tools with which to recreate neural tissue in vitro and produce realistic disease models. This in turn requires robust and reliable systems for performing 3D in vitro culture of neural lineage cells. This review provides a state of the art update on three-dimensional culture systems for in vitro development of neural tissue, employing a wide range of scaffold types including hydrogels, solid porous polymers, fibrous materials and decellularised tissues as well as microfluidic devices and lab-on-a-chip systems. To provide some context with in vivo development of the central nervous system (CNS), we also provide a brief overview of the neural stem cell niche, neural development and neural differentiation in vitro. We conclude with a discussion of future directions for this exciting and important field of biomaterials research.
机译：了解神经退行性疾病的发展是如何对研究人员的关键挑战，而且还为更广泛的社会，鉴于发达国家的迅速老龄化。该领域的进展需要在体外​​重建神经组织并产生现实疾病模型的新工具。这反过来需要鲁棒和可靠的系统来进行神经谱系细胞的3D体外培养。本综述提供了一种关于神经组织体外发育的三维培养系统的最新现有技术，采用各种支架类型，包括水凝胶，固体多孔聚合物，纤维材料和脱细胞组织以及微流体装置和实验室 - 在芯片系统上。为了在体内开发中枢神经系统（CNS）中提供一些上下文，我们还提供了神经干细胞，神经发育和体外神经分化的简要概述。我们讨论了这种令人兴奋和重要的生物材料研究领域的未来方向。

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