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首页> 外文期刊>Cytokine >Cord blood nesfatin-1 in large for gestational age pregnancies
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Cord blood nesfatin-1 in large for gestational age pregnancies

机译：脐带血素-1大中为孕龄怀孕

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摘要

To investigate possible alterations in cord blood levels of adipokine nesfatin-1 (secreted by adipose tissue and pancreatic ??-cells and implicated in glucose metabolism and insulin resistance), as well as insulin, in large (LGA) and appropriate for gestational age (AGA) pregnancies, granted that these groups differ in body fat mass and metabolic/endocrine mechanisms. Materials and methods: Cord blood nesfatin-1 and insulin concentrations were prospectively measured in 40 LGA (9 born from diabetic and 31 from non-diabetic mothers) and 20 AGA singleton full-term infants as well as their mothers. Results: Cord blood nesfatin-1 concentrations were significantly lower in LGA compared to AGA neonates (b= -0.206, SE 0.07, p= 0.005). However, cord blood nesfatin-1 concentrations were elevated in infants born from mothers with gestational diabetes mellitus (GDM), compared to those born from non-diabetic mothers, after controlling for group (b= 0.190, SE 0.10, p= 0.05). Finally, cord blood nesfatin-1 concentrations were lower in cases of vaginal delivery (b= 0.11, SE 0.05, p= 0.042). Insulin levels were significantly elevated, as customized centiles increased (b= 0.004, SE = 0.002, p= 0.016). No significant correlation was found between insulin and nesfatin-1 in maternal and umbilical cord levels. Conclusions: In this study nesfatin-1 levels are decreased in LGA compared to AGA fetuses. Fetal nesfatin-1 concentrations are higher in cases of GDM and cord blood nesfatin-1 concentrations are lower in cases of vaginal delivery. ? 2012 Elsevier Ltd.
机译：为了研究德哌啶Nesfatin-1的脐带血水平的可能改变（由脂肪组织和胰腺α-细胞分泌，并涉及葡萄糖代谢和胰岛素抵抗），以及胰岛素，大（LGA）和适当的孕龄（ AGA）怀孕，认为这些群体的体脂质量和代谢/内分泌机制不同。材料和方法：在40 LGA（来自糖尿病患者的31例，来自非糖尿病母亲的31种）和20年患者和母亲以及母亲以及母亲以及母亲以及母亲以及母亲以及母亲以及母亲以及母亲以及他们的母亲进行脐带血素浓度和胰岛素浓度。结果：与Aga新生儿相比，LGA脐带血Nesfatin-1浓度显着降低（B = -0.206，SE 0.07，P = 0.005）。然而，与来自非糖尿病母亲的母亲（GDM）出生的婴儿患有脐带血Nesfatin-1浓度升高，与非糖尿病母亲的患者进行控制后，控制组（B = 0.190，SE 0.10，P = 0.05）。最后，在阴道递送情况下，脐带血Nesfatin-1浓度较低（B = 0.11，SE 0.05，P = 0.042）。胰岛素水平显着升高，因为定制焦炭增加（B = 0.004，SE = 0.002，P = 0.016）。在母体和脐带水平的胰岛素和Nesfatin-1之间没有发现显着的相关性。结论：在本研究中，与Aga胎儿相比，LGA中Nesfatin-1水平降低。胎儿Nesfatin-1浓度在GDM和脐带血中较高，在阴道递送情况下，脐带液-1浓度较低。还2012年elestvier有限公司

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  • 来源
    《Cytokine》 |2013年第2期|共4页
  • 作者

    BoutsikouT.; BrianaD.D.; BoutsikouM.; KafalidisG.; PiatopoulouD.; BakaS.; HassiakosD.; GourgiotisD.; Malamitsi-PuchnerA.;

  • 作者单位

    Neonatal Division 2nd Department of Obstetrics and Gynecology Athens University Medical School;

    Neonatal Division 2nd Department of Obstetrics and Gynecology Athens University Medical School;

    Neonatal Division 2nd Department of Obstetrics and Gynecology Athens University Medical School;

    Neonatal Division 2nd Department of Obstetrics and Gynecology Athens University Medical School;

    Research Laboratory of Clinical Biochemistry - Molecular Diagnostics 2nd Department of Pediatrics;

    Neonatal Division 2nd Department of Obstetrics and Gynecology Athens University Medical School;

    Neonatal Division 2nd Department of Obstetrics and Gynecology Athens University Medical School;

    Research Laboratory of Clinical Biochemistry - Molecular Diagnostics 2nd Department of Pediatrics;

    Neonatal Division 2nd Department of Obstetrics and Gynecology Athens University Medical School;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Adipokines; Fetus; Insulin resistance; Neonate; Nesfatin-1;

    机译：adipokines;胎儿;胰岛素抵抗;新生儿;nesfatin-1;

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