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首页> 外文期刊>Cytokine >NT-proBNP and CA 125 levels are associated with increased pro-inflammatory cytokines in coronary sinus serum of patients with chronic heart failure
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NT-proBNP and CA 125 levels are associated with increased pro-inflammatory cytokines in coronary sinus serum of patients with chronic heart failure

机译:NT-probnp和Ca 125水平与慢性心力衰竭患者冠状动脉窦血清中的促炎细胞因子增加有关

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Purpose: Heart failure (HF) is considered to be a complex syndrome associated with neurohormonal and cytokine activation, that contribute to its progression. There are evidences which showed that, carbohydrate antigen 125 (CA 125), a tumor marker widely used for ovarian cancer therapy monitoring, was significantly elevated in HF patients. We hypothesized that inflammatory stimuli may be responsible for amino-terminal fragment of the prohormone B-type natriuretic peptide (NT-proBNP) and CA-125 production and release in chronic HF (CHF). We aimed to measure the levels of NT-proBNP, CA 125, pro-anti-inflammatory cytokines (IL-6, IL-1 beta, IL-8, TNF-alpha and IL-4), from peripheral venous (PV) and coronary sinus (CS) blood samples, in patients with CHF and to assess their correlation with echocardiographic indices.
机译:目的:心力衰竭(HF)被认为是与神经异常和细胞因子激活相关的复杂综合征,其有助于其进展。 有证据表明,碳水化合物抗原125(CA 125),肿瘤标志物,广泛用于卵巢癌治疗监测的肿瘤标志物在HF患者中显着升高。 我们假设炎症刺激可能负责慢性HF(CHF)中预型B型利钠肽(NT-PROPNP)和Ca-125的氨基末端片段和Ca-125的产生和释放。 我们的目的是从外周静脉(PV)和 冠状动脉窦(CS)血液样本,CHF患者并评估它们与超声心动图指数的相关性。

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