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首页> 外文期刊>Acta Biochimica Polonica >Oxidative damage to DNA and antioxidant status in aging and age-related diseases
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Oxidative damage to DNA and antioxidant status in aging and age-related diseases

机译：衰老和与年龄有关的疾病对DNA的氧化损伤和抗氧化状态

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摘要

Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegenerative and cardiovascular diseases. It is, however, possible that a number of short-comings associated with gaps in our knowledge may be responsible for the failure to produce definite results when applied to understanding the role of DNA damage in aging and age-related diseases.
机译：衰老是一个复杂的过程，涉及单个细胞和整个生物体内的形态和生化变化。关于衰老如何在分子水平发生的最流行的解释之一是氧化应激假说。在许多情况下，氧化应激导致氧化修饰的大分子（包括DNA）的细胞水平随年龄而增加，而这种增加与各种病理状况有关，例如衰老，致癌作用，神经退行性疾病和心血管疾病。但是，当我们了解DNA损伤在衰老和与年龄相关的疾病中的作用时，可能有许多与我们知识上的空白有关的缺点可能导致未能产生确定的结果。

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