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首页> 美国卫生研究院文献>Medical Sciences >An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases
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An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases

机译：与乳腺癌疾病进展相关的氧化损伤和非酶类抗氧化剂状态变化的评估

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摘要

The present study was aimed to evaluate the levels of oxidative stress markers in breast diseases by measuring the 8-hydroxy-2-deoxyguanosine (8-OHdG), vitamin A, vitamin C, vitamin E, and total antioxidant status (TAS) alterations in relation to cell proliferation activity and disease progression. Significant increases in the level of the oxidative damage marker 8-OHdG and cell proliferation activity were observed in breast carcinoma patients in comparison to benign and normal controls, which were accompanied by a significant decrease in non-enzymatic antioxidants and TAS concentrations (p < 0.05). 8-OHdG and cell proliferation levels were negatively correlated with non-enzymatic antioxidants, namely, vitamin A, vitamin C, and vitamin E levels and total antioxidant activity. Altered levels of biomarkers of oxidative stress and cell proliferation activity among the malignant, the benign, and the controls suggest a correlation of increased oxidative stress and cell proliferation activity in the progression of disease in breast carcinoma patients. In conclusion, our results showed that the characterized biomarkers (i.e., low levels of vitamin A, C and D, and the TAS status; and high levels of 8-OHdG) could be used as a suitable method for detecting subjects with malignant and benign breast diseases.
机译：本研究旨在通过测量8-羟基-2-脱氧鸟苷（8-OHdG），维生素A，维生素C，维生素E和总抗氧化剂状态（TAS）的变化来评估乳腺疾病中氧化应激标志物的水平。与细胞增殖活性和疾病进展有关。与良性和正常对照组相比，乳腺癌患者的氧化损伤标记物8-OHdG水平和细胞增殖活性显着增加，同时非酶类抗氧化剂和TAS浓度显着降低（p <0.05 ）。 8-OHdG和细胞增殖水平与非酶抗氧化剂，即维生素A，维生素C和维生素E含量以及总抗氧化剂活性呈负相关。恶性肿瘤，良性肿瘤和对照组之间氧化应激和细胞增殖活性的生物标志物水平的改变提示乳腺癌患者疾病进展中氧化应激和细胞增殖活性增加的相关性。总之，我们的结果表明，特征性生物标志物（即维生素A，C和D含量低，TAS状态低；而8-OHdG含量高）可以用作检测恶性和良性受试者的合适方法。乳房疾病。

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