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Thermoresponsive polymer nanocarriers for biomedical applications

机译：用于生物医学应用的热响应性聚合物纳米载体

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摘要

Polymer nanocarriers allow drug encapsulation leading to fragile molecule protection from early degradation/metabolization, increased solubility of poorly soluble drugs and improved plasmatic half-life. However, efficiently controlling the drug release from nanocarriers is still challenging. Thermoresponsive polymers exhibiting either a lower critical solution temperature (LCST) or an upper critical solution temperature (UCST) in aqueous medium may be the key to build spatially and temporally controlled drug delivery systems. In this review, we provide an overview of LCST and UCST polymers used as building blocks for thermoresponsive nanocarriers for biomedical applications. Recent nanocarriers based on thermoresponsive polymer exhibiting unprecedented features useful for biomedical applications are also discussed. While LCST nanocarriers have been studied for over two decades, UCST nanocarriers have recently emerged and already show great potential for effective thermoresponsive drug release. (C) 2018 Elsevier B.V. All rights reserved.
机译：聚合物纳米载体允许药物包封导致脆性分子保护免于早期降解/代谢，增加可溶性药物不良和改善的血浆半衰期。然而，有效地控制来自纳米载波的药物释放仍然具有挑战性。在水性介质中表现出较低的临界溶液温度（LCST）或上临界溶液温度（UCST）的热反应性聚合物可以是构建空间和时间控制的药物递送系统的关键。在本文中，我们提供了用作生物医学应用的热响应纳米载体的构建块的LCST和UCST聚合物的概述。还讨论了基于表现出用于生物医学应用的前所未有的特征的热响应聚合物的纳米载波。虽然LCST纳米载体已经过了二十多年了，但最近出现了UCST纳米载波，并且已经出现了有效的热响应药物释放的巨大潜力。 （c）2018 Elsevier B.v.保留所有权利。

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