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首页> 外文期刊>Acta Radiologica >Monitoring of impaired phagocytic function of Kupffer cells in an obstructive cholangitis rat model using superparamagnetic iron oxide MRI and contrast-enhanced ultrasound
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Monitoring of impaired phagocytic function of Kupffer cells in an obstructive cholangitis rat model using superparamagnetic iron oxide MRI and contrast-enhanced ultrasound

机译：用超顺磁性氧化铁MRI和对比度增强超声监测阻塞性胆管炎大鼠模型中Kupffer细胞受损吞噬功能的监测

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Background Kupffer cells (KC) have an important role in the host defense in obstructive cholangitis. Non-invasive monitoring of phagocytic function of KC is pivotal. Several studies showed the possibility of non-invasive monitoring of phagocytic function of KC using superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI) or contrast-enhanced ultrasound (CEUS). Purpose To investigate the serial change of KC function using SPIO-MRI and CEUS and whether the SPIO-MRI parameter correlates with the CEUS parameter in obstructive cholangitis rat models. Material and Methods With our institutional Animal Care and Use Committee approval, 19 rats (common bile duct ligation [CBDL]: n = 9; control: n = 10) underwent SPIO-MRI and CEUS at baseline, two, and four weeks after CBDL. The relative signal loss (RSL) of T2* value on SPIO-MRI and Kupffer phase parenchymal echogenicity (KPE) on CEUS were measured. The correlation between SPIO-MRI and CEUS parameters were compared with KC count. Results In CBDL group, RSL and KPE had significantly decreased (72.1% to 29.5%, 2.7 to 0.4) at four weeks compared with those in the control group (68.2% to 58.3%, 2.5 to 3.0, P < 0.05). During the follow-up period, RSL showed significantly positive correlations with KPE (P = 0.007). In addition, at four weeks, we found RSL was positively correlated with KPE (rho = 0.750, P = 0.002). KC count was negatively correlated to RSL and KPE at four weeks (rho = -0.771, P = 0.001 and rho = -0.644, P = 0.013). Conclusion SPIO-MRI and CEUS may be equally useful for monitoring the serial changes of KC phagocytic function in vivo.
机译：背景技术Kupffer细胞（KC）在阻塞性胆管炎的宿主防御中具有重要作用。 KC吞噬功能的非侵入性监测是关键的。几项研究表明，使用超顺磁性氧化铁增强的磁共振成像（SPIO-MRI）或对比增强超声（CEUS）的KC吞噬功能的非侵入性监测的可能性。目的是使用SPIO-MRI和CEUS探讨KC功能的连续变化以及SPIO-MRI参数是否与阻塞性胆管炎大鼠模型中的CEUS参数相关。具有我们制度的体育护理和使用委员会批准的材料和方法，19只大鼠（常见的胆管结扎[CBDL]：N = 9;控制：N = 10）在基线，两次和CBDL之后四周进行斯凯赛。测量了CEU上的SPIO-MRI和Kupffer相似echogenity（KPE）的T2 *值的相对信号损失（RSL）。将SPIO-MRI和CEUS参数之间的相关性与KC计数进行比较。与对照组中的4周相比，RSL和KPE在4周内，RSL和KPE在4周内显着降低（72.1％至29.5％，2.7至0.4）（68.2％至58.3％，2.5至3.0，P <0.05）。在随访期间，RSL与KPE显着呈正相关（P = 0.007）。此外，在四周内，我们发现RSL与KPE呈正相关（rho = 0.750，p = 0.002）。在四周（RHO = -0.771，P = 0.001和RHO = -0.644，P = 0.013），KC计数与RSL和KPE负相关。结论SPIO-MRI和CEUS可能同样可用于监测体内KC吞噬功能的连续变化。

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