• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Addiction biology >Expression of functional cannabinoid CB2 receptor in VTA dopamine neurons in rats
【24h】

Expression of functional cannabinoid CB2 receptor in VTA dopamine neurons in rats

机译：函数大麻素CB2受体在大鼠VTA多巴胺神经元中的表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have recently reported the expression of functional cannabinoid CB2 receptors (CB(2)Rs) in midbrain dopamine (DA) neurons in mice. However, little is known whether CB(2)Rs are similarly expressed in rat brain because significant species differences in CB2R structures and expression are found. In situ hybridization and immunohistochemical assays detected CB2 gene and receptors in DA neurons of the ventral tegmental area (VTA), which was up-regulated in cocaine self-administration rats. Electrophysiological studies demonstrated that activation of CB(2)Rs by JWH133 inhibited VTA DA neuronal firing in single dissociated neurons. Systemic administration of JWH133 failed to alter, while local administration of JWH133 into the nucleus accumbens inhibited cocaine-enhanced extracellular DA and i. v. cocaine selfadministration. This effect was blocked by AM630, a selective CB2R antagonist. These data suggest that CB(2)Rs are expressed in VTA DA neurons and functionally modulate DA neuronal activities and cocaine self-administration behavior in rats.
机译：我们最近报道了在小鼠中中脑多巴胺（DA）神经元中的功能性大麻CB2受体（CB（2）RS）的表达。然而，很少知道CB（2）Rs是否在大鼠脑中类似地表达，因为发现CB2R结构和表达的重要种类差异。原位杂交和免疫组织化学测定检测到腹侧区域（VTA）的DA神经元中的CB2基因和受体，其在可卡因自给施用大鼠中上调。电生理学研究表明，通过JWH133激活CB（2）Rs抑制单个解离神经元中的VTA da神经元烧制。 jwh133的全身施用未能改变，同时将JWH133局部施用到核宫内，抑制可卡因增强的细胞外DA和i。 v。可卡因释放。 AM630是一种选择性CB2R拮抗剂的这种效果。这些数据表明CB（2）Rs在VTA Da神经元中表达，并且在大鼠中功能调节Da神经元活性和可卡因自我给药行为。

著录项

  • 来源
    《Addiction biology》 |2017年第3期|共14页
  • 作者

    Zhang Hai-Ying; Gao Ming; Shen Hui; Bi Guo-Hua; Yang Hong-Ju; Liu Qing-Rong; Wu Jie; Gardner Eliot L.; Bonci Antonello; Xi Zheng-Xiong;

  • 作者单位

    NIDA Mol Targets &

    Medicat Discovery Branch Neuropsychopharmacol Sect Intramural Res Program;

    St Josephs Hosp Barrow Neurol Inst Div Neurol Phoenix AZ 85013 USA;

    NIDA Synapt Plast Sect Intramural Res Program Baltimore MD 21224 USA;

    NIDA Mol Targets &

    Medicat Discovery Branch Neuropsychopharmacol Sect Intramural Res Program;

    NIDA Mol Targets &

    Medicat Discovery Branch Neuropsychopharmacol Sect Intramural Res Program;

    NIDA Mol Targets &

    Medicat Discovery Branch Neuropsychopharmacol Sect Intramural Res Program;

    St Josephs Hosp Barrow Neurol Inst Div Neurol Phoenix AZ 85013 USA;

    NIDA Mol Targets &

    Medicat Discovery Branch Neuropsychopharmacol Sect Intramural Res Program;

    NIDA Synapt Plast Sect Intramural Res Program Baltimore MD 21224 USA;

    NIDA Mol Targets &

    Medicat Discovery Branch Neuropsychopharmacol Sect Intramural Res Program;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    cannabinoid; CB2 receptor; cocaine; dopamine; JWH133; self-administration;

    机译：大麻素;CB2受体;可卡因;多巴胺;JWH133;自我管理;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号