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Continuously Substituted Solid Solutions of Organic Co-Crystals

机译：连续替代有机共晶体的固溶体

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摘要

Solid solutions of isonicotinamide(2):[fumaric acid((x))succinic acid((1-x))](t)) co-crystals were prepared. The system is anchored by two isostructural bimolecular co-crystals with compositions IN(2)SA(1) and IN(2)FA(1), respectively. The IN2:[FA(x)SA((1-x))](1) solid solutions of the co-crystals were formed using both solid-state grinding and solution crystallization. The solid solutions were found to be distinct from physical mixtures of IN(2)SA(1) and IN(2)FA(1) by analysis using differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). DSC analysis of the solid solutions showed a linear interpolation of the melting point between the binary co-crystals whereas mixtures of the two separate co-crystals showed melting of the individual phases. PXRD was consistent with linear volume expansion of the lattice parameters without a concomitant change in the full width at half-maximum for the diffraction peaks for the solid solutions, but peak broadening and bimodality were observed for physical mixtures. Both techniques provided independent evidence that the solid solutions were a single phase and not physical mixtures of the two binary co-crystals.
机译：制备异烟酰胺（2）：[富马酸（（x））琥珀酸（（1-x））]（t））共晶体的固溶体。该系统由分别具有成分IN（2）SA（1）和IN（2）FA（1）的两个同构双分子共晶体锚定。共晶的IN2：[FA（x）SA（（1-x））]（1）固溶体使用固态研磨和溶液结晶法形成。通过使用差示扫描量热法（DSC）和粉末X射线衍射（PXRD）进行分析，发现固溶体不同于IN（2）SA（1）和IN（2）FA（1）的物理混合物。固溶体的DSC分析显示二元共晶体之间的熔点的线性内插，而两种单独的共晶体的混合物显示各个相的熔融。 PXRD与晶格参数的线性体积膨胀相符，而固溶体的衍射峰在半峰全宽处没有随之变化，但对于物理混合物却观察到峰展宽和双峰。两种技术均提供了独立的证据，表明固溶体是单相，而不是两个二元共晶体的物理混合物。

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