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首页> 外文期刊>AIDS Research and Human Retroviruses >Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy
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Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy

机译：Tenofovir对青年骨骼健康生物标志物的影响最小，HIV接受初始抗逆转录病毒治疗

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Both HIV infection and tenofovir disoproxil fumarate (TDF) treatment adversely impact bone metabolism and may lead to osteopenia, which has critical implications for youth with HIV (YWH). This study evaluates changes in the biomarkers of bone metabolism and inflammation among YWH receiving initial treatment with TDF- and non-TDF-containing antiretroviral therapies (ARTs). YWH [n = 23, median age 21 years (range 18-24), 87% male, 61% African American] were assessed for inflammatory and bone metabolism biomarkers at enrollment, after 48 weeks of TDF-containing ART, and 96 weeks of ART without TDF with continued viral suppression. Spearman's rank correlation evaluated biomarker associations. Bone alkaline phosphatase, parathyroid hormone, and osteopontin increased after TDF treatment. All fell after TDF was discontinued. Levels of RANKL and osteoprotegerin did not change throughout the study. There was little correlation between biomarkers of bone metabolism and either macrophage or lymphocyte activation at any time point. Our results establish baseline associations between bone metabolism and immune biomarkers for this population, and find that before CD4 T cell decline chronic inflammation does not perturb biomarkers of bone metabolism among YWH. The adverse effects of TDF on bone health may be marginal for YWH at the early stages of disease.
机译：艾滋病毒感染和替诺福韦解毒型富马酸莫酸盐（TDF）治疗不利地影响骨代谢，可能导致骨质增长，这对青少年具有关键影响（YWH）。本研究评估骨代谢生物标志物的变化，接受含有TDF和非TDF的抗逆转录病毒治疗（工艺）的初始治疗的YWH之间的炎症和炎症。 YWH [n = 23，21岁（范围18-24），87％男性，61％的非洲裔美国人]评估炎症和骨代谢生物标志物，在含TDF的艺术品48周后，炎症和骨代谢生物标志物，96周没有TDF的艺术，具有持续的病毒抑制。 Spearman的排名相关评估了生物标志物关联。 TDF处理后，甲硫醛磷酸酶，甲状旁腺激素和骨桥蛋白增加。在停止TDF之后都跌倒了。 RANKL和骨蛋白酶的水平在整个研究中没有改变。骨代谢生物标志物与任何时间点之间的生物标志物和巨噬细胞或淋巴细胞活化之间几乎没有相关性。我们的结果建立了骨代谢与免疫生物标志物之间的基线关联，并发现在CD4 T细胞下降之前，慢性炎症并不能使YWH之间的骨代谢的生物标志物。 TDF对骨骼健康的不利影响可能是疾病早期阶段的YWH的边缘。

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