The Association of WNT16 Polymorphisms with the CD4(+) T Cell Count in the HIV-Infected Population

Xie Li; Huang Yiyong; Zhong Jianing; Wei Huiping; Chen Siyuan; Jiang Kongmei; Li Shan; Qin Xue

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The Association of WNT16 Polymorphisms with the CD4(+) T Cell Count in the HIV-Infected Population

机译：WNT16多态性与CD4（+）T细胞计数在艾滋病毒感染群体中的关联

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摘要

WNT16 is one of the 19 members of the human Wnt gene family, and it plays a positive role in lymphocyte proliferation. We investigated the possible association of WNT16 rs3801385 and rs2707466 with the CD4(+) T cell count among the HIV-infected population in Guangxi, China. A total of 93 HIV-1-infected patients aged 20-75 years were separated into a CD4(+) T cell count >= 200/mm(3) group (60 cases) and a = 200/mm(3) in the context of HIV infections compared with the control group (odds ratio [OR] = 2.22, 95% confidence interval [CI]: 1.10-4.48, p = .026, and OR = 2.33, 95% CI: 1.03-5.29, p = .044, respectively). When stratified by viral load, this positive association was significantly strengthened in the viral load group of <20 copies/mL. In contrast, there was no significant difference in any genotype and allele of rs3801385 between the patients and healthy controls. In conclusion, the results suggest that the rs2707466 A allele may have a positive effect on maintaining the CD4(+) T cell count in HIV-infected individuals.

机译：Wnt16是人类Wnt基因家族的19个成员之一，它在淋巴细胞增殖中发挥着积极作用。我们调查了Wnt16 RS3801385和RS2707466的可能关联与中国广西艾滋病毒感染群体中的CD4（+）T细胞计数。共有93例20-75岁的感染患者分为CD4（+）T细胞计数> = 200 / mm（3）组（60例）和A = 200 / mm（3）与对照组相比，HIV感染的背景（差距[或] = 2.22,95％置信区间[CI]：1.10-4.48，P = .026，或= 2.33,95％CI：1.03-5.29，P = .044分别）。当通过病毒载荷分层时，在<20拷贝/ ml的病毒载荷组中显着强化该阳性关联。相比之下，患者与健康对照之间的任何基因型和等位基因没有显着差异。总之，结果表明，RS2707466 A等位基因可能对维持艾滋病毒感染的个体中的CD4（+）T细胞计数具有积极影响。

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《AIDS Research and Human Retroviruses》 |2020年第2期|共3页
作者
Xie Li; Huang Yiyong; Zhong Jianing; Wei Huiping; Chen Siyuan; Jiang Kongmei; Li Shan; Qin Xue;
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作者单位

Guangxi Med Univ Affiliated Hosp 2 Dept Clin Lab Nanning Guangxi Peoples R China;

Guangxi Med Univ Affiliated Hosp 1 Dept Clin Lab 6 Shuang Yong Rd Nanning 530021 Guangxi;

Guangxi Med Univ Affiliated Hosp 1 Dept Clin Lab 6 Shuang Yong Rd Nanning 530021 Guangxi;

Guangxi Med Univ Affiliated Hosp 1 Dept Clin Lab 6 Shuang Yong Rd Nanning 530021 Guangxi;

Guangxi Med Univ Affiliated Hosp 1 Dept Clin Lab 6 Shuang Yong Rd Nanning 530021 Guangxi;

Guangxi Med Univ Affiliated Hosp 2 Dept Clin Lab Nanning Guangxi Peoples R China;

Guangxi Med Univ Affiliated Hosp 1 Dept Clin Lab 6 Shuang Yong Rd Nanning 530021 Guangxi;

Guangxi Med Univ Affiliated Hosp 1 Dept Clin Lab 6 Shuang Yong Rd Nanning 530021 Guangxi;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
WNT16; polymorphisms; CD4(+) T cell; HIV-1 infection; viral load;

机译：Wnt16;多态性;CD4（+）T细胞;HIV-1感染;病毒载荷;

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1. The Association of WNT16 Polymorphisms with the CD4(+) T Cell Count in the HIV-Infected Population [J] . Xie Li, Huang Yiyong, Zhong Jianing, AIDS Research and Human Retroviruses . 2020,第2期

机译：WNT16多态性与CD4（+）T细胞计数在艾滋病毒感染群体中的关联
2. Mortality and its predictors among antiretroviral therapy na?ve HIV-infected individuals with CD4 cell count ≥350 cells/mm3 compared to the general population: data from a population-based prospective HIV cohort in Uganda [J] . Ben Masiira, Kathy Baisley, Billy N. Mayanja, Global Health Action . 2014,第1期

机译：与普通人群相比，抗逆转录病毒疗法中的死亡率及其预测因子的初次感染HIV的CD4细胞计数≥350细胞/ mm3的个体：来自乌干达基于人群的预期HIV队列数据
3. Mortality and its predictors among antiretroviral therapy na?ve HIV-infected individuals with CD4 cell count ≥350 cells/mm3 compared to the general population: data from a population-based prospective HIV cohort in Uganda [J] . Ben Masiira, Kathy Baisley, Billy N. Mayanja, Global Health Action . 2014,第1期

机译：与普通人群相比，抗逆转录病毒疗法中的死亡率及其预测因子的初次感染HIV的CD4细胞计数≥350细胞/ mm3的个体：来自乌干达基于人群的预期HIV队列数据
4. Analysis of Treatment for HIV-infected Patients Considering CD4 T Cell Count in STI [C] . Ki Yeon Park, Han Byul Chung, Chung Choo Chung SICE-ICASE International Joint Conference . 2006

机译：考虑STI CD4 T细胞计数的艾滋病毒感染患者治疗分析
5. Associations of T-cell phenotypes with persistent oral thrush at CD4 positive cell counts greater than 500 per cubic millimeter and their interactions with progression of HIV disease (Immune deficiency). [D] . Foster, Virginia Brown. 2001

机译：T细胞表型与持续口鹅口疮在CD4阳性细胞数上的关联大于每立方毫米500，以及它们与HIV疾病进展（免疫缺陷）的相互作用。
6. Mortality and its predictors among antiretroviral therapy naïve HIV-infected individuals with CD4 cell count ≥350 cells/mm3 compared to the general population: data from a population-based prospective HIV cohort in Uganda [O] . Ben Masiira, Kathy Baisley, Billy N. Mayanja, 2014

机译：与一般人群相比抗逆转录病毒疗法中未感染艾滋病毒的人的CD4细胞计数≥350细胞/ mm3的死亡率及其预测因素：来自乌干达基于人群的预期HIV队列数据
7. Mortality and its predictors among antiretroviral therapy naïve HIV-infected individuals with CD4 cell count ≥350 cells/mm3 compared to the general population: data from a population-based prospective HIV cohort in Uganda [O] . Ben Masiira, Kathy Baisley, Billy N. Mayanja, 2014

机译：与普通人群相比，CD4细胞计数≥350细胞/ mm3的抗HIV病毒感染者的抗逆转录病毒疗法的死亡率及其预测因素：来自乌干达的基于人群的前瞻性HIV队列的数据

The Association of WNT16 Polymorphisms with the CD4(+) T Cell Count in the HIV-Infected Population

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